Insitome’s Fun Neanderthal and Metabolism Apps

Insitome, pronounced In-sight-ome, as described here, a startup by Spencer Wells, former Director of The Genographic Project, is offering two (and soon more) apps that I found quite interesting.

Insitome partners with Helix, so you’re really working with two different companies, but it’s relatively transparent to the consumer.  Helix sequences your exome for a one time cost that is significantly under market price.

This article explains the relationship between Helix and Insitome.  If you google the title of the article, shown in the link below, you can then see the article behind the paywall for free. Yes, I’m quoted in the article, along with Spencer Wells, of course.

https://www.genomeweb.com/sequencing/insitome-launches-first-app-helix-questions-remain-about-impact-ancestry-test-providers

However, with Helix, you CANNOT obtain your raw Exome data to download and use as you wish.  The reason that Exome sequencing is offered by Helix at an artificially low price ($80 versus about $500) is that Helix provides a new marketplace model where Helix and their various partners are hoping to recoup Helix’s Exome processing investment when you purchase multiple application products from their partners – kind of like the Apple app store.

Hence, the Insitome motto “One and never done.”

This marketplace model means that you sequence your Exome once through Helix, and then purchase applications from partner developers like Insitome who utilize your Exome sequence to provide you with an array of results. You don’t purchase the Exome sequencing separately, it’s generally included with your first app purchase, and then future app purchases are simply add-ons.

By way of example, let’s just say that all apps cost $50. (They actually range widely from lower to higher.)  Your first app would cost $50 plus $80 for the Exome test for a total of $130.  Your second and all future apps would only cost $50.

I do have some thoughts to share on the Helix model, which I will do in a future article, but for now, I just want to share with you my Neanderthal and Metabolism results that I purchased through Insitome.

These were a lot of fun!

Neanderthal

As a history buff, I have always been very interested in Neanderthals – an interest which was multiplied exponentially when it was discovered that Neanderthals didn’t die out, just another dead branch on the human tree. Instead, Neanderthals assimilated into the European and Asian populations, along with their cousins, the Denisovans to become part of who we are today, assuming you have any European or Asian heritage.

I wrote about the Neanderthal discovery and what it means to us in the following articles:

Insitome Insights

Insitome’s platform is called Insights and is focused on providing you, the consumer, with insights into yourself.

Today, you can purchase two apps, the Neanderthal and Metabolism apps, and as you can see, there are more apps in the development stages. That’s the blurred out block.  I strained to see, but no luck!

Let’s see what the two apps available today tell me about myself.

I’m always looking for more insight, pardon that pun😊

Neanderthal

I was excited to see what Insitome had to say about my Neanderthal heritage.  Let that sink in for a minute.

Neanderthal HERITAGE.

Yes, in me.  I’ll never know their names, but pieces of those ancestors from tens of thoursands of years ago remain inside of me today – running in my veins! Enough to be recognizable when compared to the genomes recovered from Neanderthal and Denisovan bones.

When I was tested several years ago by the Genographic project, I received an initial Neanderthal percentage breakdown, but now, I’m going to be able to identify which of my traits are thanks to my Neanderthal ancestors.

Drum roll….

So, I carry 1.1% Neanderthal DNA. That’s less than I thought.

It’s absolutely imperative that you click on the “Begin Story” blue link just below your percentages.  In fact, this may just be the very best part of this app.  I would expect no less from Spencer Wells.

Your story is also interactive so in the section where the story discusses the adaptations for hair and skin color (pigmentation), and why they occurred, you can click to see your own result at the proper place.

It’s interesting that my Neanderthal results are smaller with Insitome than they were with the Genographic Project where I’m reported to be .8% Neanderthal and 1.4% Denisovan for a combined total of 2.2%.

Insitome refers to Denisovans as Eastern Neanderthal, so their 1.1% combines the Neanderthal and Denisovan.

What the Genographic Project does not provide is the breakdown of which of my traits are Neanderthal and which are Modern Human.

Insitome does.

And here’s the detail to be discovered by clicking on the trait itself, in this case, “Learning.”

I can then view my full history.

Interesting, there are 14 genes in total that comprise this cluster which I inherited from my Neanderthal forbearers.

Sure enough, further research shows that TANC1 is reported to be the center of visual learning. Isn’t it ironic that the Neanderthals were stereotyped to be lumbering, almost “pre-human,” unintelligent and their language was assumed to be a series of grunts with no perceptible words. We’re now learning more about our ancestors and they don’t seem to be nearly as primitive as first supposed.

Next, let’s look at Pathogen Recognition.

Again, clicking on “Read More” displays the full history which is just fascinating.

It’s interesting to think that my Neanderthal immune receptors for pathogen recognition may be the only reason I’m here today.  It makes me wonder how many times that this Neanderthal remnant saved the day, and no one ever knew, until now!

Metabolism

The second Insitome app that I purchased is Metabolism.

I need to tell you, up front, the same thing I told Spencer Wells. I’m extremely apprehensive about metabolism applications and claims made regarding metabolism and nutrition, especially those made by someone with something to sell you afterwards – like supplements.

Spencer told me that the Insitome app is nothing like that, so I purchased it to see.  He was right – the Insitome app tells me which of 8 metabolism traits I inherited from either the Hunter-Gatherer or the Farmer group of people.

In the history of humans, hunter-gatherers preceded farmers.  Farming began in the Fertile Crescent about 10,000 years ago and then slowly worked its way to Europe. Both of these groups had specific metabolic traits that their descendants carry today.

As with the Neanderthal app, please click on “Begin Story” for the fascinating history behind the information.

Did you know that your brain utilizes roughly 25% of your daily calorie intake?  Neither did I!

And beer, beer is a part of my heritage.

I knew it!

Well, let’s just say that explains a lot.

Look, both Alcohol Flush and Alcohol Tolerance are traits that one inherits from either their Hunter-Gatherer ancestors or their Farmer ancestors.

I carry the Hunter-Gatherer version of both alcohol related traits – meaning the more ancient versions.

This means I get sick more slowly from drinking too much alcohol.

Um, is that a good thing or a bad thing? I’m not sure.

Summary

You can see for yourself which of the following traits are inherited from your Neanderthal ancestors:

  • Pigmentation
  • Sun Damage Repair
  • Torso Shape
  • Learning
  • Fat Storage
  • High Altitude Adaptation
  • Interpreting Immune Signals
  • Pathogen Recognition
  • Viral Immune Response
  • Muscle Growth and Development

Which ones do you think you have that are Neanderthal?

As far as Metabolism is concerned, you will learn which of the following traits are the older Hunter-Gatherer or the younger Farmer.

  • Alcohol Flush
  • Alcohol Tolerance
  • Caffeine Metabolism
  • Calcium Absorption
  • Fat Synthesis
  • Glucose Tolerance
  • Vitamin D Absorption

If you’re going to order these tests, play a little game and write down which traits will be Neanderthal versus Modern Human and Hunter-Gatherer versus Farmer versions.

Then, order your kit or kits below and see if you were right.

  • Insitome’s Metabolism including Helix processing at $119.99 or $39.99 if you’ve already had Helix sequence your DNA.  However, right now, the Cyber Sale is in effect until November 27th and Helix processing is free, meaning the entire price for this app is only $39.99 and shipping is free too.
  • Insitome’s Neanderthal including Helix processing for $199.99 or $29.99 if you’ve already had Helix sequence your DNA.  The Cyber sale means that the total cost for this app is only $29.99 which includes Helix processing and shipping.

To get the Cyber Sale prices for these apps, just click on the blue links above and then on the “Order” button, and your promo code is automatically applied, adjusting the price accordingly.

Hmmm, I’m wondering if my kids and grandkids would like this for Christmas! Education disguised as fun. Maybe the adults could test the alcohol flush reaction as part of our own family scientific study.

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Standard Disclosure

This standard disclosure appears at the bottom of every article in compliance with the FTC Guidelines.

Hot links are provided to Family Tree DNA, where appropriate.  If you wish to purchase one of their products, and you click through one of the links in an article to Family Tree DNA, or on the sidebar of this blog, I receive a small contribution if you make a purchase.  Clicking through the link does not affect the price you pay.  This affiliate relationship helps to keep this publication, with more than 900 articles about all aspects of genetic genealogy, free for everyone.

I do not accept sponsorship for this blog, nor do I write paid articles, nor do I accept contributions of any type from any vendor in order to review any product, etc.  In fact, I pay a premium price to prevent ads from appearing on this blog.

When reviewing products, in most cases, I pay the same price and order in the same way as any other consumer. If not, I state very clearly in the article any special consideration received.  In other words, you are reading my opinions as a long-time consumer and consultant in the genetic genealogy field.

I will never link to a product about which I have reservations or qualms, either about the product or about the company offering the product.  I only recommend products that I use myself and bring value to the genetic genealogy community.  If you wonder why there aren’t more links, that’s why and that’s my commitment to you.

Thank you for your readership, your ongoing support and for purchasing through the affiliate link if you are interested in making a purchase at Family Tree DNA, or one of the affiliate links below:

Affiliate links are limited to:

Cynthia Wells – A Light Gone Too Soon

It sounds trite to say that I’m sorry she’s gone, but I am.

Cynthia is one of those people that everyone, and I do mean everyone, liked.  She lit up the room everyplace she went, improved everything she touched and encouraged everyone, always.

And now, she has passed from this earth.

Cynthia was a long time dedicated genetic genealogist, and an even longer time genealogist. She joined the genetic genealogy community in the olden days, more than a dozen years ago and managed the Wells and Lay projects at Family Tree DNA.

She attended the conference for project administrators sponsored by Family Tree DNA every fall in Houston, and I was looking forward to seeing her next week.

Sadly, that’s not to be.

In short, those of us in the trenches together over the years have formed a family, of sorts.

I first met Cynthia perhaps a dozen years ago when we sat by each other at lunch at one of the early conferences and began discussing Indian traders in the south. She sent me an unpublished resource, along with a book, and refused any reimbursement at all. That’s the kind of person she was.

Cynthia worked as a volunteer for the LDS Church and spoke at several genealogy conferences and meetings, often attending at her own expense, bringing the message and joy of genetic genealogy to many.

A day or so before her passing, Cynthia returned from a trip to the Middle East, in particular, the Holy Land, to celebrate her husband’s retirement and the beginning of the next chapter of their life together. She was anxiously planning a two-year mission trip with her husband when she passed away.

What a heartbreaking situation her husband faces. My heart aches for him, her children and grandchildren.

Fortunately, Cynthia’s legacy is not lost.

You can read more about her passion in her speaker profile for Genetic Genealogy Ireland here.

You can listen to her lovely southern drawl as she gives her presentation about Reconstructing Irish-Caribbean Ancestry here.

You can read Cynthia’s obituary here.

If you are a member of the ISOGG Facebook group, you can read the remembrances of her friends along with photos of the places she traveled on behalf of genetic genealogy, truly a lovely tribute, here.

Cynthia’s unexpected and untimely passing reminds us all about how tenuous and fragile life is – and why we should say and do what needs to be said and done while we can. Cherish those we love and value every minute. We really don’t know when it might be our last.

Rest in Peace Cynthia – you truly have made the world a better place and improved the lives of those who were graced enough to walk a few steps with you along the way.

FTDNA Unlock Sale, Upload Fix & Triangulation

Three important pieces of information today:

  • The unlock at Family Tree DNA for transferred autosomal files from other vendors is only $10 for the duration of October, a savings of almost 50% with the coupon code.
  • After unlocking your results, you can triangulate your Ancestry, 23andMe or MyHeritage results with your Family Tree DNA matches using the new third party tool, The Triangulator.
  • For those who have been having problems transferring Ancestry results to Family Tree DNA, a fix.

Unlock Sale

You can always transfer your results from either 23andMe (V3 or V4), Ancestry (V1 or V2) or MyHeritage to Family Tree DNA for free and see your matches, but to unlock the chromosome browser, an extremely useful tool that shows you exactly where your DNA matches, your ethnicity estimates (myOrigins) or your ancientOrigins, you need to unlock the results which normally costs $19 – a lot less than a second DNA test.

For the rest of October, which is only 4 days, you can unlock your results for only $10 with the coupon code below.

Please keep in mind that the 23andMe V4 test, in production between November 2013 and August 2017, and the Ancestry V2 test, in production since May 2016, are not fully compatible with the Family Tree DNA test and transferring those results only provide you with your closest matches – normally about 20-25% of the total matches you would have if you took a Family Finder test. My Ancestry V2 transfer test provides me with 3rd-5th cousins and my smallest matching segment is 14cM. To obtain all of the matches you would have with a fully compatible DNA test, order a Family Finder test from Family Tree DNA for $69.

The Ancestry V1 test (used until May 2016), 23andMe V3 test (used until November 2013) and MyHeritage transfer files are fully compatible, so no need to order a Family Finder test if you can transfer one of those.

Triangulate

After you transfer and unlock, you’ll be able to use the new Triangulator tool on your Family Tree DNA matches. The Triangulator is easy and simple and no longer requires talking everyone into transferring their results to GedMatch to be able to triangulate.

You can read about the new Triangulator tool, here.

Transfer Troubles

Some people have been experiencing problems with transferring some Ancestry files to Family Tree DNA.

You can find Ancestry download instructions here.

There are three possible solutions for the problem. I suggest trying them in this order:

  • Delete the first download file (so you don’t get them confused) and download the Ancestry raw data file again. There have been instances of incomplete downloads. Do not open the file before uploading to Family Tree DNA.
  • Open the transfer file after downloading from Ancestry and search for the text “V1” or “V2” in the first few rows. If it says V1, change it to V2 and it if says V2, change it to V1. Save and close the file. Do not rezip the file. Just upload it to Family Tree DNA.
  • A solution for upload issues that do not resolve with one of the two steps above has been discussed on the Family Tree DNA forums. A third-party tool converts an Ancestry raw data file into a format accepted by Family Tree DNA using a blank template of a known V2 working file. You can find the tool and instructions here. There are no known issues with V1 files uploading.

Summary

With the unlock sale, the transfer fix and the new Triangulation tool, now is definitely the time to transfer those files so you can match and triangulate Ancestry, 23andMe and MyHeritage files with your matches at Family Tree DNA. You never know what you’ll find.

Click here to transfer or unlock files, or to order the Family Finder test. Remember, the code for the $10 unlock is ATUL1017.

Have fun and don’t stay up all night triangulating like I did!

_____________________________________________________________________

Standard Disclosure

This standard disclosure appears at the bottom of every article in compliance with the FTC Guidelines.

Hot links are provided to Family Tree DNA, where appropriate. If you wish to purchase one of their products, and you click through one of the links in an article to Family Tree DNA, or on the sidebar of this blog, I receive a small contribution if you make a purchase. Clicking through the link does not affect the price you pay. This affiliate relationship helps to keep this publication, with more than 850 articles about all aspects of genetic genealogy, free for everyone.

I do not accept sponsorship for this blog, nor do I write paid articles, nor do I accept contributions of any type from any vendor in order to review any product, etc. In fact, I pay a premium price to prevent ads from appearing on this blog.

When reviewing products, in most cases, I pay the same price and order in the same way as any other consumer. If not, I state very clearly in the article any special consideration received. In other words, you are reading my opinions as a long-time consumer and consultant in the genetic genealogy field.

I will never link to a product about which I have reservations or qualms, either about the product or about the company offering the product. I only recommend products that I use myself and bring value to the genetic genealogy community. If you wonder why there aren’t more links, that’s why and that’s my commitment to you.

Thank you for your readership, your ongoing support and for purchasing through the affiliate link if you are interested in making a purchase at Family Tree DNA.

Ireland’s Wicklow Mountains

Sometime in the night, hurricane Ophelia departed Dublin, like an unwelcome guest. Her banshee shrieking ceased, and in the morning, the day broke on my second full day in Ireland with glistening sunshine, like Mother Nature was trying to sooth the wounds Ophelia imparted yesterday.

The day began with a leisurely drive along the coast to the south of Dublin.

I knew Brian and I were going to the Wicklow Mountains, but I didn’t realize there were really two ranges, the Dublin Mountains and the Wicklow Mountains, and they hug the coastline in many places. Truthfully, before this trip, I never realized that Ireland had mountains. I think of Ireland, green fields and Shamrocks.

The nice thing, for the Irish, is that these ranges of stunningly beautiful mountains aren’t remote – meaning they are only an hour or an hour and a half away from Dublin – but feels like a million miles.

Keep in mind that yesterday was a hurricane, and this morning’s temperature was 45F, with a real feel temperature of 42 – so I really wasn’t sure what we would find.

I was floating on the edge of sleep again, as Brian drove along in the glorious, warm sunshine when I heard his voice in the distance say something about swimming. Surely, I was dreaming…

The Forty Foot

The first place we stopped was the “old swimming hole.” Of course, I thought Brian was kidding when he suggested that I look to see if someone was swimming today. No one in their right mind would be swimming. It was freezing cold. Both in the water and out, PLUS, all that storm debris was everyplace. Brian has a great sense of humor.

But then, he suggested again.

Did Brian think I was born yesterday and fell off the turnip truck?

Well, OK, I’ll look, just to humor Brian.

Ahem…

Yep, those things bobbing around in the water are people. By the way, in the background, the church spires of Dublin in the distance. I barely noticed the spires.

Now I don’t know exactly how to mention this politely, so I’m not going to try.

It’s nude swimming. Now, if this was the south of France in the summertime or the Caribbean perhaps, I wouldn’t have thought anything about nude swimming,.  But Ireland, in October?  Seriously?

And these swimmers aren’t kids either. There was no one under 60. I met one man today, Patrick, who was 86, and yes, Patrick was swimming, or at least he was on his way to swim…in his speedo which I think got removed at water’s edge. And Patrick claimed he wasn’t cold. I touched his arm, and he really wasn’t cold. He bid us a quick goodbye and said he had to hurry up and get into that frigid water before he got cold. HUH???

Do these people have antifreeze in their veins.

And they do this every single day, rain, shine, sleet, snow, hurricane.

This area used to be for gentlemen swimmers only, but a few years ago, women staged a protest, a swim-in, for lack of another word, and now both genders swim daily, year round, 365 days a year. In their birthday suits.

They do try to be quite modest when “changing,” so not to cause traffic accidents or shock American tourists.

Then there was this guy who was dancing, for lack of any better description. Actually, kind of dancing and yoga combined with a very loose towel hula skirt. Or maybe this was interpretive dance. I took a video of his great reveal, but I can’t share it with you. 

You can swim in the buff, however, you CANNOT take your dog swimming, so don’t even think about it. Rules are rules, after all.

By now I was fully awake and in desperate need of coffee, but none was to be found. Is Ireland, between hurricane Ophelia and our recycled teenaged swimmers, actually an alternate reality? I was beginning to wonder.

And you want to hear what’s worse? Brian knew them. All of them. By name. Except for the dancer who Brian says is new. But Brian swears he doesn’t know how to swim.

I, I , I just don’t know quite what to think😊

The Coastline

Nature continued to amaze and delight today.

In this picture, you can see Howth across the bay. I was standing on top of that hill taking photos of the lighthouse below in a hurricane 24 hours earlier. So, we’ve literally come full circle. What a difference a day makes.

This Napoleonic watch tower, built around 1804, was later the home of James Joyce when he wrote Ulysses. These watch towers, all within sight of each other, dot the coastline.

Our next stop at Colemore Harbour was punctuated by beautiful old boats on the ramp among homes of the rich and sometimes famous.

Another watchtower, this one on an island.

This view looking south shows the Wicklow mountains, where we were heading. I never realized that Ireland had mountains.

Mary Herrell’s death wish makes a lot more sense now. She said that when she died, she wanted her body to be placed on top of Herrald Mountain in Wilkes County, NC so her soul could fly back to Ireland. It’s no wonder Appalachia felt so much at home to these transplants.

Now, if Mary would just have told us her maiden name and where she was from in Ireland….

The Wicklow Mountains

Castles, old and new line this route. This is where Enya lives.

Most roads in the mountains are small and only wide enough for one car. People simply go slow and share, with no honking of horns or road rage.

Then there’s your obligatory ram standing beside the road. Better than in the road. By the way, in many places, there are no fences.

Sugarloaf Mountain.

The Powerscourt Hotel complex was originally a castle. Can you tell?

Beautiful, sheltered courtyard.

Look at these spider-stompers!

The formal gardens were beautiful, but the tea and scones beckoned me.

We had a proper tea. I had a pear and vanilla scone, and Brian had a currant scone. No wonder we didn’t eat lunch until 2:30.

Sheep grazing in the shadow of the mountains, beside the hedges of rosebushes. You’re looking at the rose hips. This area looks a LOT like Scotland.

Unlike Appalachia, there are few little creeks and brooks here, so imagine my surprise when we came around the corner to this beauty. I think Brian said this waterfall is 420 feet high and it’s stunning.

The rock at the bottom actually has a large hole where you can see the water on the other side.

Next, we drove along the bog fields where little grows except heather.

Here’s a closeup of yellow heather.

Brian knows the horses and they come to the fence when he makes whinnying sounds. He’s pretty darned good and says he has known these horses for 20 years now. The white horse, Mr. Ed, does not allow you to feed the brown horse nor does the white horse like to be petted. “Feed me, but for heaven’s sake, don’t touch me…or anyone else either.” Reminds me of my cats.

This amazing highlands property is owned by the Guinness family. The lake has actually been engineered to actually look like Guinness beer.

The black granite at the bottom of the lake makes the water look black, and the family had millions of tons of white sand brought in to look like Guinness “foam” around the edges when it’s drawn from the tap.

What do you think? Did it work?

This entire valley is owned by the Guinness family and is breathtakingly beautiful in it’s stark ruggedness.

Did I mention Braveheart and the Viking series were filmed here? I need to watch Braveheart again.

It’s simply stunning everyplace you look.

On to the pub for lunch. I just love this painting on the ceiling above the fireplace. And I love Irish pubs too!

And the Guinness stew, to die for. No picture of the stew. I thought of it too late.

A monastery, now in ruins, was founded in the 6th century by St. Kevin in Glendalough.

A chiseled cross was supposed to offer protection and stop everyone…except the Vikings didn’t understand apparently.

The cemetery is still in use or at least was until 1900 or so.

However, the abbey is in ruins.

One man lived to be 106. Imagine that in a time before antibiotics or any other type of modern medicine. He had to have been both lucky and genetically predisposed to longevity – not to mention a lack of Viking invasions during his lifetime.

I love that tree line on the far hill.

This stone tiled building may have been a kitchen.

The tower as viewed through the ruins of the monastery.

It seems that life in this part of Ireland revolved around sheep, land, the church and either whiskey or beer.

I hope that someone has cataloged these stones for Find-a-grave.

This area of Ireland is known for its woven wools.

Headed back to Dublin at the day’s end.

I can certainly see why Mary Herrall wanted her soul to fly back to “sweet old Ireland.”

Tomorrow, New Grange, Knowth and Tara, land of Niall of the Nine Hostages, my ancestor.

Meeting Ophelia in Dublin

If I was an Irish lad or lass,
I’d think today was a blast.
Ophelia was a gift
No working on my shift.
Of course.
Of course.

I’m no fool.
There’s no school or car pool
No busses or planes.
Too windy to ride,
I’m taking this in stride.
Must stay at home,
For safety’s concern…
Of course.
Of course.

Too unsafe to go out
And walk about.
Except to the pub
For some grub,
Good company,
And Guinness
Of course,
Of course.

Ophelia’s winds are harsh
And will blow you right into the marsh,
So don’t walk or ride,
Just kinda slide,
Holding onto whatever you can
Or find yourself a stout man.
On the way to the pub
For that lovely pub grub.
And to discuss why you have to stay home
Cause it’s too dangerous to roam…
Of course.
Of course.

Ok, so my Irish ditty writing could use some improvement, but go easy on me.  After all, I did survive a hurricane in Ireland. And, I learned exactly how the Irish handle a weather event like this.

First, they refer to the windy day as being a “fresh day.” Yea, it’s fresh alright, it’ll blow the stink right off of you, along with exfoliate at least the top layer of skin.

I’m sitting back in my hotel room now, listening to the wind batter the side of the building, blowing objects from other buildings into this one. I swear, the rafters are lifting up and down, slamming like the screen door just before my mother yelled at me, “don’t slam the screen.” Too late! Wham, again.

Many places, especially along the coastline, were shuttered with plywood today and noplace, and I do literally mean noplace except for a couple pubs, was open. It’s not like Brian and I didn’t try.

I know I’m part Irish now, because I was determined to make lemonade out of lemons.

You see, that’s what the Irish do. That is pretty much their approach to life. Not just Ophelia.

Ophelia Makes Landfall

This is by far the weirdest hurricane I’ve ever weathered.

While the hurricane was striking, there were bands of rain, which is typical, interspersed with bands of sunshine, which isn’t.

The wind was very warm – also very unusual.

There were no thunderstorms or tornadoes, at least not yet.

But the wind.  My God, the wind. It was truly brutal – registering gusts as high as 119 MPH. The worst storm Ireland has seen in 50 years.

Brian and I discovered an elderly man laying on the sidewalk. Brian pulled over, stopped, we got out and tried to help the man by recruiting two other men walking along to try to help him to his feet. The man was in quite a bit of pain, and it became evident that he had badly hurt himself. We gently lowered him back on the sidewalk, as there was no place else to put him, and called the ambulance. Of course we stayed with him and tried to bring him some comfort. The police and firetruck arrived within a minute or so, and about that time a huge gust of wind came along and blew me into a police officer who was standing beside me, nearly knocking us both over.

I apologized profusely. I mean, assaulting a police officer isn’t something I normally do.

Enter the Irish sense of humor.

His partner, who witnessed the event, of course, says, “Brian always has that effect on women.” I was embarrassed. Brian (yes, the third Brian of the day) then very kindly took ahold of my arm so that I wasn’t blown elsewhere with a much less soft landing.

The wind was just that strong.

Jim Cantore strong.

The. Irish. Are. Such. Genuinely. Nice. People.

Brian

Let me introduce you to the first Brian, Brian O’Reilly. You can’t get more Irish than that!

He’s amazing.

I found Brian through a series of referrals before my arrival in Dublin.

He’s a professional tour guide, taxi owner and driver.

In other words, if he’s not working with individuals, or hotels, he fills in the time by doing general taxi work.

He drives a nice mini-van with the driver’s seat on the “wrong side” by American perspective.

The perfect person to make lemonade with.

Unfortunately, many of the things he had planned for me today, we couldn’t do. We had already regrouped once from the countryside to Dublin city, because of the weather. Brian said they never get hurricanes here, so he truly didn’t think this one would strike.

Many people felt the same way initially, but last night the TV was full of doom and gloom, trying to convince people to stay home and be safe. This storm hasn’t deposited a lot of rain, but the winds have been devastating. It’s like straight-line-winds for hours on end.

Trees, branches, roofing materials – all flying around.

So, in essence Ireland shut down and told everyone to stay home. Of course, everyone welcomed “Holiday Ophelia.”

That means that there were only two places people were…home and the pub.

The Pub

The local pub in Ireland is a public gathering place.

And just because you’re not local doesn’t mean that you’re out of place. They just immediately adopt you and inside of 10 minutes, you’re one of them, exchanging stories like you’ve always been there.

Ok, here’s proof.

This is my new friend, Edna. We had SO MUCH FUN. I drank my first Guinness. Yes, that’s it in the baby glass. I wasn’t at all sure that I liked Guinness, but I do.

She was an experienced, expert Guinness drinker.

The Irish have traditions for everything, and drinking Guinness is no exception.

For women, newbies or “pansys,” (their word, not mine), they add a couple drops of black current to Guinness. It makes the Guinness slightly sweet and more palatable for those who have not yet acquired the taste. Edna, my new friend, asked the bartender to do that for me.

He looked at me deadpan and said, “No. You drink Guinness neat or not at all. It’s against our religion here to sully our Guinness with anything.” He paused for a minute, then looked at me and said, “Well, drink up.” I did, and liked Guinness. It tastes like a slightly smoky beer. He smiled and said, “See, you didn’t need any of that pansy stuff,” turned and walked away, leaving Edna and me in stitches and shrieking peals of laughter.

Yea, I know, all of you who know me are saying to yourself, “I can’t believe this, Roberta, in a bar.” However, pubs are not the same as bars. Pubs are local and safe gathering places, probably originating as fires around which our very ancient ancestors gathered in the evenings to share some fermented something-or-other and revel in tales about the wooly mammoths they had seen that day.

Plus, I had Brian with me, or better put, he had me with him.

Now here’s a shocker. Not all of the pubs were open, which simply made the ones that were more crowded, and more interesting. Somehow ironic that everyone was gathered around the TV, moaning about damage and danger reports and discussing why it was too dangerous for them to go to work.  Of course, going to the pub was just fine.  Why would you ask? Makes perfectly good sense.

And friendly?  You haven’t met friendly until you’ve met the Irish. Let’s put it this way, I got hugged and kissed goodbye (on the check) by Edna’s lover (her word, not mine), Brian, (the second Brian), on the way out the door.

They don’t do the cheek kiss thing as much here as they do on the European mainland, but they obviously have adopted that custom at least partially. Or Brian was getting cheeky with me, one or the other. Pardon the pun.

Ok, enough about the pubs.

Howth

Ophelia was scheduled to arrive in Dublin between 1 and 3 today. She was a prompt guest and is obviously staying overnight because she’s still here and the winds have not abated one bit, as of midnight.

Brian is a native Dubliner and we decided, based upon his experience, to visit a beautiful fishing village north of Dublin in the morning, because a fishing village in driving rain isn’t fun – and that’s what we expected in the afternoon.

Howth is on the Bay of Dublin and where the fishing fleet is located. Seafood doesn’t get fresher than at this famous restaurant, literally at the end of the dock. Of course, it was closed.

On the wharf, the warehouses are interspersed with little shops.

I desperately wanted to eat at the Octopussy Seafood Tapas restaurant, but they weren’t open. And weren’t planning to open, given the weather, although they did have to stand outside and discuss it for several minutes.

Another local place that looked like a lot of fun!

I wonder how much this storm cost Ireland.

One place warned visitors that they had only a skeleton crew today.

The Pier West Art Studio was open, albeit boarded up. Perhaps this cupid’s head is a good luck piece. My friend who lives on the Outer Banks in North Carolina has a good luck angel strapped to one of the support stilts of her house. Maybe this is the same kind of protection.

Speaking of art, we saw this beautiful chain saw carving along the way.

The views from Howth were spectacular.

I love seaside villages anyway, but today, with the weather event, Mother Nature was truly putting on a show!

I must admit, I found this warning to be quite humorous, especially since it was cobblestones that laid me low previously.

The red sign tells people that the pier is close today due to weather. Well, duh, you can barely walk and stand upright, but somehow, people managed and walked the pier anyway.

Brian and I kept to the edge away from the water and didn’t walk beyond the sign. Neither of us was interested in pulling the other out.

No fishing boats out today.

As the day wore on, about noon, the sea and sky became more menacing. Brian said he has never seen waves like there were today, although they don’t look bad in this little cove.

Given the wind on the top of the hill where I was standing, I couldn’t get closer to this lighthouse by the sea. By this time, the wind was driving the sand mixed with rain in sheets that felt like sandpaper on your skin. Dublin city was across the bay, if you could have seen that far.

Brian knew all of the good places to stop for photography.

On the way out of town, we drove up into the village of Howth itself and discovered this stunning old church ruin with its cemetery intact.

This is just so Irish. A church ruin, a tiny old cemetery and it’s all tucked quaintly beside modern homes and utilities on a steep hillside just above the sea.

Have I mentioned that all signs here are in Gaelic as well as English? A dual language provision is actually in the Irish constitution, based on the fact that the English had tried to eradicate the “Irish heritage” by eliminating the Gaelic language, not to mention the Catholic religion.

Today, Gaelic is taught in the schools and Brian’s grandchildren attend a school where the children are taught 75% of their studies in Gaelic and 25% in English.

Many Irish buildings are quite ancient by US standards.

Everything in the old country is, well, old. They literally use everything until it can’t be used anymore. At that time, depending on the structure, what it is and where it is, they either tear it down or abandon it. Buildings currently in use are often hundreds of years old.

If these old pub steps could talk…

And these steps, across from the ruined church, literally leading no place. However, at some time they clearly led someplace and I’d love to know that story.

It was time to head back to Dublin. Even though we were only about 10 miles north, it felt extremely rural, like we had crossed a time barrier into an earlier domain.

Back in Dublin, we discovered that all of the Starbucks were closed. Heresy, I tell you. Chocolate shops all closed too. Imagine! What’s a woman to do?

Find a pub, of course. The Irish answer for everything. We did find a nice pub for lunch.

Deviled Lamb Kidney’s anyone?

I’ve already introduced you to Edna, of course. Ahh, our lunch was too short but what a fun experience. In Ireland, everyone speaks to and talks to everyone else. It’s catching. I’m doing in too, but in the US the same behavior would be view as borderline predatory.

Next, we tried to visit various gardens, museums and even the Guinness Brewery, but everything was closed. So we drove to see the sights.

I think Brian told me that this was the Irish Parliament building, but I was fascinated by the gate.

Notice that there are many green leaves on the ground because they are being stripped from the trees by the wind today.

Notice too that right this minute, the sun was out, but the wind was still intense and unrelenting. It was a very, very odd weather day.

Brian says this is the most photographed door in Dublin.

The Irish refer to this as the “Pepper Canister Church,” smack dab in the middle of the street.

Today, no tourists or competition, so opportunities for wonderful photos – and no traffic either, which was rather uncanny. Brian indicated that normally traffic during the week is neck to neck all day long in the city. Did the Rapture come to pass and I got left behind in Ireland with Brian?

Did you notice the rainbow? I can’t find the words for how bright and intense this rainbow was. It was actually startling as we turned the corner, like fire in the sky. 

I suggested to Brian that perhaps we should find the pot at the end. I mean, after all, we ARE in Ireland.

This rainbow lasted for quite a long time, but then, was gone as quickly as it had appeared.  A beautiful end to an exciting day, making lemons out of lemonade!

Ophelia wasn’t an invited guest, and hasn’t left yet, but she assuredly didn’t ruin the day and perhaps made it more memorable. How many other people can reminisce about their Irish hurricane?

Right now, aside from the actual physical danger of the winds blowing you over, like that poor man, and flying debris, the biggest problem is that almost half a million people are without power. Trees blowing over have taken many power lines with them. Furthermore, phone carriers are impaired and TV and internet are spotty, at best. The mast that holds the equipment is snapped in half outside the hotel.

Tomorrow, if possible, Brian and I will visit the coast south of Dublin and the Wicklow Mountains. From the sounds of the wind right now, maybe not. Unless it stops, we may have to find a way to make more lemonade!

Ophelia – A Hurricane In Ireland

If you find this a bit unbelievable, well, so do I.

I’ve learned an awful lot about hurricanes in Ireland over these past couple days, including that they aren’t generally called hurricanes. Cyclone appears to the official name, but here in Dublin, they call them “Big Winds.” As in, “the last big wind we had was in 1987,” or worse yet, if you want to feel really old, “the last big wind we had was before I was born.” It’s also called the Great Storm of 1987.

It appears that the “greatest storm ever”, which of course means in the history we are aware of, was recorded when a freak storm occurred between the nights of January 6 and 7, 1839. It was titled, “The Night of the Big Wind.” This article is a fascinating read, and although it doesn’t happen often, severe storms of hurricanes clearly do happen in Ireland. And they have likely happened in Ireland forever and maybe one in a lifetime would have been known to our ancestors.

Well, big wind, hurricane, typhoon or cyclone, a rose by any other name…and this one is named Ophelia.

In Hamlet’s tale, Ophelia, a name he appears to have made up, is a women tragically torn and who then then descends into madness.

That’s a good description, if I’ve ever heard one, for a hurricane that is going to hit Ireland – way off track…tomorrow…exactly 30 years to the day since the last “big one.”

It’s insane!

Now, of course, this would happen to me. I swear, is Michael Lacopo hiding in my suitcase? Am I related to him and don’t know it? Do we both carry a calamity gene? This kind of thing is only supposed to happen to him, and I mean, it happens regularly to him. In the genetic genealogy community, everyone asks Michael his travel arrangements before booking their own, because everyone knows what happens to Michael. I’m not kidding!

Hurricane Magnet

On the other hand, this isn’t exactly my first hurricane. I seem to attract them, somehow. In fact, I actually got married in the lull caused by the eye of hurricane Isabella, in Ohio. Yes, I said, in Ohio. And then there’s the hurricane on the Outer Banks where I waited too long to evacuate and the road was washing out as I tried to make my way to the Bonner bridge before the road was washed entirely into the sea. That was one of those trips that if you start, you don’t dare stop. And then there was the next hurricane too that sandblasted the side of my car, also on the outer banks….but never mind…I’m sure you get the drift. And suffice it to say I don’t even live anyplace near a hurricane state.

So, apparently I have some sort of hurricane magnetism…and it’s showing again. Mind you, I couldn’t even so much as muster up a rainstorm at home for weeks on end this summer.

Dublin

This trip to Dublin, I swear, has been jinxed from the beginning. I hesitate to say any more, because I don’t want to further jinx the trip, but let’s just say that this trip has been in jeopardy more than once, beginning with the fall in July that happened two days after I booked my (uncancellable) accommodations. You’ve already read about the resulting DVT.

My doctor authorized this trip, but ONLY IF I promised to fly first class, with seat room more befitting my “body type.” I do not fit well into 17 inch seats. Who over the age of about 10 does?

To say I nearly had a coronary or a stroke when I saw the price of the first class upgrade is an understatement. But by that time, it was either lose the 10 days unrefundable hotel and flight I had already booked or upgrade. Do you want to bleed this way or that way?

So, the upgrade was booked and I wrapped both legs in ace bandages for the journey, which she also made me promise. I then discovered that the only way to keep ace bandages in place was to use leggings, or in my case, long underwear given that I didn’t have any leggings.

So, I arrived at the airport looking and walking stiffly like a mummy which earned me a special “groin pat down” in security, even though I am already TSA prechecked. And lots of questions about why my legs were wrapped. I so wanted to say, “because I’m a mummy, in fact I’m a grand-mummy too,” but because I’ve heard that the TSA agents have no sense of humor whatsoever, for once in my lifetime, I kept my mouth shut and better judgement prevailed. Otherwise, I’d still be at that same airport, in some small room.

After all that, what else could possibly go wrong?

Let’s just say something did not agree with me. I was concerned that I wasn’t going to be able to make the actual flight, given that I was apparently homesteading in the bathroom. Not only that, there were there gate changes, in different concourses (of course), with me only able to hobble.

I then received one of “those” phone calls, while camped out in the bathroom.

You know, one of the phone calls we know that is eventually inevitable but we dread intensely. Yes, a family member had passed away, unexpectedly.

So there I sat, in the airport bathroom, in jeopardy of missing a flight in a different concourse, flying into an area that was expecting a hurricane, sobbing as I received the news and trying to compose myself enough to call my family members most affected. I had by now pretty much turned into an emotional wreck.

I considered bagging the entire trip, but there was nothing to be done at home, and the trip, still uncancellable, was extremely costly. The only blessing is that my family member’s passing was swift. So, I managed to find the correct gate, at the last minute, and deposit myself on the plane. I’m not a drinker, but I had two drinks just the same, which for me is absolutely unheard of. I’m going to have to change that answer on my medical records from “no alcohol” to 2 per year.

Yesterday ended as day faded into night and then, just a very few hours later, night faded back into day after an artificially shortened night because you’re flying into the dawn.

So, as I sit here in a historical hotel in Dublin this later afternoon, the sky is darkening once again, but this time, it’s not because of night’s approach. It’s the wrath of Ophelia beginning.

I told you that I’d take you along on this trip, but this wasn’t exactly what I meant. Just the same, let’s make lemonade out of lemons!

We get to experience Dublin together and maybe we will have a great adventure!

Emerald Isle Beginnings

The day began very early, as the sunlight emerged on the horizon and the plane flew above or through some of Ophelia’s turbulence. It was strong enough to wake me up, bouncing around in the plane. Belongings were hitting the floor. The captain woke us up to tell us to fasten our seatbelts.

We passed over the turbulence that was Ophelia, who would catch up with me again in a couple days, playing our own personal cat and mouse game it seems.

When we landed in Ireland, leaving Ophelia behind in the Atlantic, the sun was bright and beautiful. You can definitely see where the nickname “Emerald Isle” originated. That sunshine was to be short-lived.

Of course, I couldn’t check into my hotel when I arrived, because the rooms weren’t quite yet ready. That’s what happens when you arrive at 9 in the morning.

My choices were to sit in the lobby and wait…and wait…and wait…or do something else. I chose to have a tea and some soda bread with black currant and raspberry jams and then take a hop-on-hop-off tour that took a total of about two and a half hours. That would hopefully give the hotel enough time to prepare a room and I would get to see something of Dublin.

By early evening, the winds, gloom and clouds of Ophelia had replaced the beautiful sunshine, but thankfully, not until after I had finished my tour.

Dublin in Under Three Hours

The first thing I learned on the tour is where the word Donnybrook came from.

Donnybrook

This church was the location between Ballsbridge and Donnybrook where the locals prayed for the souls of Donnybrook, and prayed for many of them to go away, it appears.

Our guide told us that while initially, Donnybrook was a local medieval fair, beginning in about the year 800, that over time it devolved into something that included copious amounts of drinking and various degrees of alcohol infused arguing and fighting. Hence, the genesis of the word Donnybrook.

Now, I assure you that my ancestors were involved in this, because, well, my ancestors were always involved in anything like this. I wouldn’t know what to do with a well-behaved ancestor. I would wonder how they ever got into my pedigree chart. Must surely be an NPE!

I would love, just love to visit Donnybrook fair for a day, back in the 1200s or 1300s, perhaps, with whichever of my ancestors might have been living here at the time. Oh, what fun we would have!

Doors

Dublin is also the land of doors. In Georgian neighborhoods, the only thing you are allowed to change on historical homes is the color of the door, hence, this. The guide said it also helps you find the right house when you come home late at night from the pub, or Donnybrook.

And, are you ready for this, the cheapest of these cost upwards of a million dollars, and I’m not talking about the entire row of apartments, but just one flat. And those are the cheap seats.

Markets

Sunday is the day in Dublin for art and street fairs. The fence along this public park sports the offerings of local artists and many people are walking and chatting.

Small markets appear all over the old part of the city, in nooks and crannies.

Along the River Liffey

The Irish famine shaped the people and the history of Ireland as well as the US, Canada and other diaspora regions. Due to the famine, many died, and many immigrated as well between 1840 and 1850.

This photo doesn’t do this memorial justice. Take a minute and look at this short YouTube video.

In the same video, you also get a look at Ireland’s harp bridge. This isn’t the official name, but I also discovered that in Dublin, everything has a nickname and about 90% of them are not printable here.

This bridge can also be played like a harp using fire hoses with pressurized water to vibrate the strings.

Embassy District

The American embassy.

The RDS, or Royal Dublin Society center, where Genetic Genealogy Ireland is going to be held later this week. I can hardly wait!

The Clayton Ballsbridge, my hotel, was next on the circuit.

This beautiful old building was opened as a Masonic Girl’s School in the 1880s.

The tile in the entryway is just beautiful.

Of course, I’m on the 6th floor and with Ophelia headed our way tomorrow, we’ll see just how well this building is constructed. I love old buildings though, and would much prefer to stay in a historic structure if possible.

Architecture

Put another way, the only buildings I’m not cracked up about are modern lifeless ones. I just love quaint, artistic buildings.

The Ferryman, along the river, across from what was the oldest Viking settlement known in Ireland. The descendants of those men probably have a brew in this pub today.

One of the things I dearly love about European cities is the intermingling of the old, meaning medieval, and the new. This is just a typical street scene. Lots of people walking everyplace.

Here’s another example of a beautiful old church behind the Guinness Brewery.

Guinness

Guinness, we have to talk about Guinness for a minute.

I know Guinness as a brand of beer, but in Dublin, it’s a wealthy family who happens to brew beer…the favorite beer of the Irish, it seems.

The Guinness Storehouse, which is also Ireland’s most popular tour, isn’t just a place, but a complex.

The Brewery and the Guinness Storehouse may be where I’ll be touring later this week, given that we were told that they “never close.” I hope that isn’t a dare to Ophelia.

Now, at one point, the hop-on-hop-off bus parked at a stop for a full 40 minutes. So it became the hop-off bus because if you wanted to go to the bathroom or do anything except sit there, you got off.

Now I’m not saying this was planned, but the location where the bus stopped just happened to be right in front of a pub. Like 15 feet from the door

Not just a pub, but a little hole-in-the-wall Irish pub, Madigans – the kind of place I’m just a sucker for. These places are either wonderful or terrible, with very little inbetween. I asked the tour guide where he might suggest something to do, close, for half an hour or so, and he suggested a bowl of soup in the pub.

Mnnnn, now that sounded good.

Ok, Ok, he really suggested soup and a Guinness.

Ok, well maybe he suggested he Guinness part and then muttered something about soup in a barely audible whisper at the end.

WhatEVER.

Did you know that soup in Ireland comes with soda bread? Well, actually, I think everything in Ireland comes with soda bread, from what I’ve seen.

I’m working my way up to Guinness. It’s pretty dark. So I started with a lager, Clonmel 1650. That’s good. I think I’m officially Irish now. My ancestors would be proud, even though I did ask for the smallest one possible.

And there is traditional Irish music on Thursday and Sunday evenings. Oh my. I’m not saying where I’ll be later in the week, but this is certainly a candidate.

Did I mention, that the Irish like to drink….a lot? Irish poet Brendan Breham described himself as a drinker with a writing problem. That’s about right, judging from what I saw today.

I don’t even know what to say.  No, it’s not Halloween here.

Need I say more?

So far, I’m feeling my Irish roots, but I’m not pedaling anything nor am I wearing a Viking horned hat, at least not yet. The week is still young though. No promises about tomorrow or the next day either.

The Week Ahead

What does this week hold, especially with Ophelia? I don’t know.

I do know one thing though, this trip cost far too much to not have fun…so I’m going to. Come hell or high water.  Ummm, maybe I shouldn’t have said that last part…

Someone suggested that if we can’t sightsee, we could pub crawl to get a look at the local flavor, of course. The Irish are extremely helpful like that. Seriously, they are some of the nicest people you’ll ever meet. Perhaps because they are all mellow, or at least have that mellow gene.

Actually, that pub crawl sounds pretty interesting, especially it if includes traditional Irish music and Guinness. After all, Madigan’s pub is on the ground floor, it’s safe, safer than the 6th floor.  Yea…that’s it, all in the interest of safety. That’s my story and I’m sticking to it!

So, if you don’t hear from me for the rest of the week:

  • I’ve met Ophelia and she was a worthy opponent
  • I’ve fallen in love with Dublin and am busy looking for a house in the even poorer district, probably someplace in Donnybrook.
  • Ophelia was no big whoop and I’m back to sightseeing with Brian.  Who’s Brian, you ask?  Well, you’ll just have to wait to find out.
  • Make something up about what Roberta is doing.

Just thinking that option 4 might be by far the most interesting, and you guys might just have some good ideas too.

You know, I’m wondering if that howling that I’m hearing outside is ghosts, singing Irishmen who drank a bit too much, werewolves or Ophelia has come to call. It’s an unworldly sound, whatever it is.

Promethease 2017

For those who aren’t acquainted with Promethease, they are a service that provides a comprehensive “health” report based on autosomal DNA results uploaded from the major testing companies.  You receive an informational report about your genetic health risks and some traits as reported in numerous academic studies that are archived and categorized relative to genetic information.

Quoting Promethease, they say:

Promethease is a literature retrieval system that builds a personal DNA report based on connecting a file of DNA genotypes to the scientific findings cited in SNPedia.

Please note that if you took the 23andMe test for health information, Promethease provides you with exponentially more information – and you can utilize your 23andMe file to obtain that information. If you tested at any of the other major vendors, you can utilize those reports as well, either separately or together.

I originally wrote about Promethease in December of 2013. At that time, I uploaded the files from various testing vendors to Promethease one by one and compared the results. Four years in this industry is forever, so I’m doing this again to share my results. There is a lot more information available from Promethease, and the testing vendors files have changed too.

This time, I’m uploading my Exome data, a very different DNA test than consumers receive at the typical genetic genealogy testing companies. You can read about this test in the article, Genos – A Medically Focused DNA Exome Test.

Keep in mind that even if you uploaded your autosomal file before and received results, Promethease adds new references as they become available, so your information from a couple years ago is out of date. The good news is that Promethease is very inexpensive, typically between $5 and $10.

What Does Promethease Do?

Promethease reports raw information, meaning that they do not massage or interpret this information for you. In other words, for a particular disease or trait, if there are 10 articles that report on that particular DNA location, based on your SNPs (one from Mom and one from Dad,) 2 information sources might indicate a possible increased risk, 5 might be neither good nor bad, and 3 might indicate a possible lower risk. Promethease shows you all 10, not distilling the 10 into a compilation or summary of your risk factors.

Promethease is NOT DIAGNOSTIC. Only a physician can diagnose complex illnesses correctly, incorporating genetic information.

I should note here that very few mutations are absolute, with a few notable exceptions like Huntington’s Chorea. In most cases, just because you have a specific mutation indicating an elevated risk, does NOT means you’ll ever get that disease. Other factors such as lifestyle, nutrition and environment are involved, as well as elements we don’t yet understand today.

Important

If you decide to submit your information to Promethease, it’s very important for you to understand and take the following points into consideration:

  • The DNA tests you are uploading are not medical tests. They do not test all possible locations. Furthermore, occasionally, tests run by different vendors produce different results at specific locations. Those differing results can and do produce conflicting information about traits or mutations associated with that location.
  • Testing errors occur.
  • Promethease results are not diagnostic, only informational.
  • If you are concerned about your health, either before or after testing, you should take the results and your concerns to your physician for interpretation in your particular situation. (I am not a doctor. This is common sense.)
  • The field of genetics, including medical genetics, is undergoing a steep learning curve. Very little is cast in concrete. Sometimes we learn that what we thought we knew previously was incorrect.
  • You cannot “unsee” what you will learn about your own genes and mutations. Be sure you really want to know before you participate in this type of learning.

Having said all of that, let me share some interesting information about my results with you.

My Results

I recently uploaded my Genos Exome test, which tests a LOT more locations than any of the typical genetic genealogy tests – 50 million as compared to less than 1 million in the typical genealogy autosomal tests. I utilized Genos results on purpose, after developing a DVT (deep vein thrombosis – a blood clot) in my leg after a fall and after a flight, both. I wanted to see if I carry any genetic propensity for developing DVTs, or if it had just been a combination of circumstantial factors other than genetics. I discovered that I don’t carry any known genetic predisposition to DVTs or other clotting issues. Neither did my parents, at least not that I know of.

Promethease returned a total of 45,595 locations with informational results of some type, meaning those locations had been found in medical or academic literature housed at SNPedia.

Of those locations, 41,766 were “good,” 104 were “bad,” and 3,725 were “not set” meaning neither good nor bad.

The great news is that you don’t need to read all of the results, but can search or see any results that are relevant for any particular word. So you can sort for “clot,” “thrombosis” or even something like “kidney” or “liver,” in addition to seeing and sorting information in various other ways.

Most everyone looks at their “bad” mutations first. Fortunately, most people don’t have many and often bad doesn’t really mean “bad,” simply a slight elevated risk.

The Process

When considering whether or not to utilize Promethease, you might want to take a look at the video provided on their main web page.

Of course, to proceed, you’ll need to actually READ the legal verbiage and click that you accept to proceed.

Please click on any image to enlarge.

Promethease said this, and I said this, but I want to say it again.

You may discover things that will worry you. You may find conflicting information about a trait or mutation. You cannot “unsee” this once you’ve seen it.

Vendor Upload Files

You can upload your results from any of the vendors, noted above, as well as see example reports. Occasionally when a vendor changes something in their file, or changes testing chips, there will be a delay while Promethease makes adaptations. As I write this today, Promethease is working to handle the 23andMe V5 chip which is the new Illumina GSA chip.

One VERY interesting feature is that you can upload your results from multiple vendors and Promethease will combine them to provide you with one report. This costs a little more – mine was $17.  If I didn’t taken the Exome test, I would have uploaded all of my other files for combination.

Actually, after I uploaded my Exome file and ran the results, I did upload the rest. I’ll be publishing an article shortly with the results of that comparison titled “Imputation Analysis Utilizing Promethease.”

I would NOT utilize files from vendors that impute DNA data and include imputed information in your download data file. Of the vendors listed, I know that today MyHeritage makes use of imputed data on their site, but only downloads your actual tested locations, so their file would be fine to use.

DNA.Land facilitates uploads from other vendors, then imputes additional results, allowing you to download the imputed data file. I would not suggest using this file.

At this link, Promethease discusses imputation and says that some results from imputed information will be unreliable. I would recommend AGAINST using the imputed data. You will have no idea which results are from your real test and from the imputed data, that isn’t actually yours.

If you choose to use an imputed file, I would suggest that you also separately run the same file that you uploaded to DNA.Land in order to see which of your report locations are real and which are imputed by comparing the results of the two separate runs.

Promethease provides information, shown below, about the various vendors and vendor files. Note that some are not accepted, and some are less reliable.

It’s interesting that the Family Tree DNA Big Y test is accepted in addition to their Family Finder autosomal test.

The Results

Processing takes about 20 minutes and you will receive an e-mail when processing is complete with a link to both view and download your report. Click “download” which provides a zip file. Results are only held on the Promethease website for 45 days unless you make a selection to retain your results on the website to enable future processing.

Promethease provides a nice tutorial, both via their video and onscreen as well.

Click the link in the e-mail to see your results.

Promethease results are color coded with red being a probable pathogenic result (meaning potentially concerning, or bad), green being a good or protective result and grey meaning not assigned as bad or good – just information.

In total, I had the following categories of results utilizing my Genos file:

  • Probably Pathogenic, red – 104
  • Not Set, grey – 3725
  • Protective, green – 41,766

Please note that while red equals bad, that’s a relative thing. For example, having a “bad” mutation that MAY elevate your risk to 1.2% from 1% isn’t really terribly concerning. Most of my “bad” mutations fall into this category, and may have good offsetting mutations for the same condition. So, no jumping to conclusions allowed and no panicking, please.

Here’s my first result. It’s grey.

Whew, I’m a female!

You can see that I have 45,595 results returned, 10 being shown on the screen and the rest of the 45,595 being held in reserve and visible by sorting any number of ways, including by key word in the search box shown top right above. Below, lots of other sort options.

Here’s an example of a “grey” result when I searched for “eye color.”

You can see that this genotype, or result, as described, influences eye color.  I carry the nucleotides G and G, noted beside the rs id, where an A is required for the propensity to blue or grey eyes.

From this information, we know that my children received a G from me, because that’s all I have to give them, but if they received an A from their father, their eyes could be blue or grey.

Caution

If you don’t want to know, and I mean really know about your medically connected mutations, don’t utilize Promethease.

If you are prone to anxiety or worry, this might not be for you. If you are a hypochondriac, for Heaven’s sake, don’t use Promethease.

If you do want to know, run Promethease occasionally, because new SNPs are being added to the data base regularly.

Be cautious about introducing this entire report into your medical record, especially given that the state of health care and pre-existing condition coverage is uncertain in the future in the US. However, be vigilant and inform your physician of anything that might be relevant to your conditions or treatment, or especially any variants that might help them diagnose a condition or tailor medications.

While I am providing an informational article about this product, I am not specifically recommending or suggesting that anyone utilize Promethease.  That is an individual decision that everyone needs to make personally after weighing all the factors listed above, plus any not mentioned.

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