New Worldview at 23andMe

23andMe released a new version of their Ancestry Composition – and guess what – my Native Ancestry is shown for the first time.  Yahoo!  It was previously shown at 23andMe as Asian, and the chromosomal locations have changed somewhat as well.

23andMe has greatly improved their product offering, moving from a significantly outdated 3 step ethnicity approach, European, African and Asian, to a multi-tiered, regional platform.

Let’s take a look at what we have today.

Here’s me in my new worldview at 23andMe under the Ancestry Composition tab.  The regions where I have ancestry are brightly colored.

rje world 23andme

Looking at my ethnic breakdown, shown on the right on my page, but shown below here, you can see that I’m 99.4% European, 0.5% Native American and 0.1% unassigned.

rje world 23andme 2

The worldwide breakdown into regions is quite interesting as well.

rjeregion23andme

By highlighting any region item, above, it shows you the corresponding region on your worldview, below.  Pretty cool.

rjeregion23andme2

They’ve updated the Chromosome View as well.  Previously, my Chromosome View looked like this:

rjechromosome view old 23andme

Now, it looks like this, reflecting the new regional ethnicity information.

rjechromosome view 23andme new

Another setting that you can manipulate is found in the drop down box in the upper right corner. It has 3 options, standard estimate, conservative estimate and speculative.  In my case, this changes the results very little, the Native moving around a bit, but the regions within Europe do change.  Be sure to take a look at all of these.  The drop down box is easy to miss.

One thing I do really like about this new rollout is that the X chromosome is included.  You can see it at the bottom of the list.  This is new and has been promised for a long time.

One feature that I would very much like to see is the ability to determine which, if any, of my matches actually match me on the segments determined to be Native American.  I realize that not everyone at 23andMe is interested in genealogy, but if you could contact them and say, “Hey, we match on my Native segment – let’s see if we can find some common ancestry,” it might generate enough interest to garner a response.  I would like to find a way to use these results more effectively.  I think there is a lot of unrecognized potential just waiting to be harvested.

All in all, a significant step forward for 23andMe.  For me, not a lot of new information.  I discovered that I have some Native genes on chromosome 2 in addition to chromosome 1.  My African ancestry picked up elsewhere is missing here.  Fortunately, my Native American heritage is now classified as such, and not Asian.  However, on the speculative view, I still have a smidgen of Asian, likely from the Native American heritage.  I really like the 3 choices in how to display results, conservative, standard and speculative.

As soon as the National Geographic Geno 2.0 ethnicity information is available, I’ll be comparing all the results from the various companies against my known genealogical heritage and taking a look at all of those results combined.  Stay tuned….things are really getting interesting!

______________________________________________________________

Disclosure

I receive a small contribution when you click on some of the links to vendors in my articles. This does NOT increase the price you pay but helps me to keep the lights on and this informational blog free for everyone. Please click on the links in the articles or to the vendors below if you are purchasing products or DNA testing.

Thank you so much.

DNA Purchases and Free Transfers

Genealogy Services

Genealogy Research

News From National Geographic

AA010638

National Geographic released some additional information today about both Version 1.0 and the new Version 2.0 of its tests and the program as a whole.

Phase 1 – Geno 1.0

“Our first phase drew participation from more than a half-million participants from over 130 countries. It is evidence of enormous interest in deep ancestry among the global public — tracing the paths their ancestors took as they migrated around the world over the past 60,000 years,” said Project Director Dr. Spencer Wells, a population geneticist and National Geographic Explorer-in-Residence.  “Now, the Genographic Project’s second phase creates an even greater citizen science opportunity — and the more people who participate, the more our scientific knowledge will grow.”

spread6_1Final

During Genographic’s first phase, Wells and project scientists traveled the globe to collaborate with tens of thousands of indigenous people, whose genetics are particularly significant in determining human migratory routes. Wells and Pierre Zalloua, principal investigator in the Middle East, for example, collaborated with the Toubou people of northern Chad, whose DNA has revealed insights into ancient migrations across the Sahara. Genographic’s principal investigator in the Oceana region, Lisa Matisoo-Smith, worked intensively with people on the remote south Pacific island of Emirau, collecting DNA samples and sharing the results with them.

geno_2_Spencer Wells watches as men from the town of Gouro pray to commemorate the end of Ramadan_Photo by David Evans_Gouro, Chad

The Genographic Project team worked with individuals, institutions and organizations all over the world to find and tell their genetic stories, including the prime minister of Kazakhstan, who invited Wells and his colleagues to collect DNA samples in his country after becoming fascinated with his family story as revealed by his Genographic kit results; the people of Barbados, who requested a study on the pattern of diversity in the country using the public participation kits; and members of the public in South Africa, who learned that they carry links to the region’s earliest inhabitants, the San people, in addition to genetic lineages from elsewhere in Africa, India and Europe.

geno_2_The bright head turbins worn by Chadean men are for more than just show, a valuable adaptation to the harsh Saharan Desert they helps to keep valuable water in and annoying sand out_Photo by David Evans

The project also tested 200 random people on a single day on a block of Queens, New York, to demonstrate the area’s diversity. In a collaboration with cellist Yo-Yo Ma’s multidisciplinary education foundation The Silk Road Project, more than 400 students at four New York City public schools swabbed their cheeks and traced their ancient ancestry.

geno_2_A student looks at the Genographic Project map_Photo by Lindsay Maiorana

Geno 2.0 – New Interface

National Geographic says that participants will receive their results through a newly designed, multi-platform Web experience. In addition to full visualizations of their migratory path and regional affiliations, participants can share information on their genealogy to inform scientists about recent migratory events. These stories also can be shared with the broader Genographic Project community; as the number of contributions grows, the experience will become richer, as participants learn more about themselves and their shared ancestry. Results also can be shared as an infographic for social platforms.

Scientific Papers Published

Seven years into this project, benefits are being reaped at unprecedented levels.  Already, project results have led to the publication of 35 scientific papers, reporting results such as the origin of Caucasian languages, the early routes of migrations out of Africa, the footprint of the Phoenicians in the Mediterranean, the genetic impact of the Crusades and the genetic origins of the Romanian royal dynasty that included Vlad the Impaler. The project’s DNA results and analysis are stored in a database that is the largest collection of human anthropological genetic information ever assembled.

NGS Picture ID:1049085

“The Genographic Project truly represents another facet of a new age of exploration. The newest Genographic technology will push the limits of our research, inspiring us to learn more about ourselves and leveraging the insights gleaned so far to take citizen science and genetic testing to a whole new level,” said Terry Garcia, executive vice president of Mission Programs at National Geographic.

New Grants Available

New to the second phase of Genographic, the project will invite applications for grants from researchers around the world for projects studying the history of the human species.  Sample research topics could include the origin and spread of the Indo-European languages, genetic insights into regions of high linguistic diversity such as Papua New Guinea, the number and routes of migrations out of Africa, the origin of the Inca or the genetic impact of the spread of maize agriculture in the Americas.

geno_2_Two women in Khorong, Tajikistan_Photo by David Evans

While this press release does not mention it specifically, my understanding from previous discussions with Spencer Wells suggested that this would not be limited solely to academic researchers and that project administrators and citizen scientists’ applications would be considered as well.

Legacy Fund

Geno 2.0 continues the tradition of the Legacy Fund, established 7 years ago with the first tests.  A portion of the proceeds from the sale of Genographic Participation Kits funds project research and the Genographic Legacy Fund, which awards grants to support community-led cultural conservation and revitalization initiatives among indigenous and traditional communities around the world. So far, the Genographic Project has provided 62 Legacy Fund grants worth $1.7 million. Efforts supported by the grants include the creation of teaching materials on the ancient wisdom of the Chuj in a Maya community in Guatemala and the revitalization of indigenous languages in Nepal, India, Taiwan, French Polynesia, Mexico and Bolivia.

geno_2_A man looks into the sunset in the Sahara Desert_Photo by David Evans

New Education Initiative – GenoThreads

A new education program called GenoThreads enables science, culture and geography to be naturally woven into a shared educational experience. GenoThreads connects students and teachers around the world who are using Genographic participation kits; this allows a cross-cultural exchange between students via email and videoconference for a truly global experience. In the first GenoThreads project, high school students in Switzerland are sharing their results with those halfway across the world in Singapore.

geno_2_Spencer Wells speaks to an audience

New Website

Members of the public are encouraged to visit the Genographic Project’s newly created website at www.genographic.com.  Featuring National Geographic photography, as does this blog today, the website gives Genographic participants the opportunity to learn more about their own ancestry and find ancestral connections. The Genographic Project remains nonmedical and nonprofit, and all analysis results are placed in the public domain following scientific publication. The Genographic Project serves as an unprecedented resource for geneticists, historians, anthropologists and citizen scientists.

Excitement Surrounding Geno 2.0 Tests

There is a lot of excitement about the new Geno 2.0 tests in the genetic genealogy community, and more than a little restless shuffling of feet.  Genetic genealogists are not a patient lot, albeit from the best of motives.

We want to see our results, sooner than later, and we want to play with them.  We want to upload them to Family Tree DNA and have them integrated with the rest of our DNA tests and information, available to use – one stop shopping.  We want to download them to our computers and use them in a myriad of ways. We want to see if we gained branches, or twigs, on our haplotrees.

We want to see who we connect to, and how closely.  We want to ping our anthropological neighbors on the new website and invite them to download their information to Family Tree DNA as well.  We want more project members.  We want matches where we have none and more where we have some.

We want to know if we are Neanderthal or Denisovian, and how much.  We wonder if our minority admixture, whatever it is, will be revealed or if it’s too far back in time.  And on a research level, we want to know which populations were used, which new autosomal SNPs were discovered, and the frequencies they are found worldwide.  I know, we want, we want, we want.

Exciting tidbits arrive periodically, whetting our appetite.  We already knew that the Y-tree had to be rebuilt during vetting of the Geno 2.0 chip, but more recently, it appears that perhaps the tree is being reorganized, again, already, with the first run of data.  Such conflicted feelings.  So glad such wonderful discoveries are being made, but so impatient to see what they are.  And that’s the whole lot of us, not just a few:)

Good thing it’s December…looks like Santa has a big wish list from us to fulfill and National Geographic, indeed, is going to be one of Santa’s biggest helpers!  Now if they could just HURRY:)  Maybe we should add a dose of patience to the things we want……Nah.  I just hope lots and lots of other people want this too!!!

geno_2_A local guide signals to a lost vehicle in the Sahara Desert_Photo by David Evans

All photos are copyright protected by the National Geographic Society and used with their permission.

______________________________________________________________

Disclosure

I receive a small contribution when you click on some of the links to vendors in my articles. This does NOT increase the price you pay but helps me to keep the lights on and this informational blog free for everyone. Please click on the links in the articles or to the vendors below if you are purchasing products or DNA testing.

Thank you so much.

DNA Purchases and Free Transfers

Genealogy Services

Genealogy Research

 

little a, BIG A, Mitochondrial DNA

During my webinars this week for APG, someone asked a question about mitochondrial DNA and I told them I would follow up on my blog.  I thought I knew the answer, but I needed to be sure.

When I displayed the slide of my full sequence in the RSRS format, they noticed some of the letters were lower case.  Truthfully, since client comparisons are still in the CRS format, I hadn’t paid a lot of attention to my RSRS values except for an initial look-see when the corresponding paper came out (“A ‘Copernican’ Reassessment of the Human Mitochondrial DNA Tree from its Root”)  and the RSRS results were added to our personal page information.  I know, my bad.

In my blogs titled Citizen Science, the CRS and the RSRS and What Happened to My Mitochondrial DNA?, I explained about the CRS and the RSRS.  In a nutshell, the RSRS, the Reconstructed Sapiens Reference Sequence is the new way of interpreting mitochondrial results, comparing them to a “reconstructed” Eve instead of someone who tested in Cambridge in 1981.  That 1981 person set the standard for the CRS, or Cambridge Reference Sequence.

But soon, we will be using the RSRS.  My understanding is that the Geno 2.0 results, although only providing the haplogroup defining mutations, will be given in RSRS format.

So let’s take a look at what this person saw that caused a question.

RJE RSRS

In the last mutation in the coding region, all the way at the end, you see that a mutation is noted as C15452a.

Now let’s take a look at the CRS version.

RJE CRS

You see the same mutation, but it’s noted differently, as 15452A.

What is the difference, or maybe better asked, why the difference?

On the CRS page, the mutations are shown, as above, but there is also a second part of that page, shown below.

rje crs2

On this second part of the results, the normal value in the CRS, and the value carried by the person with the mutation in 1981, is shown.  So this is a translation table for your results.  You can see that it shows that the CRS value for location 15452 is normally C and my value is an A.

What are those Cs and As? Or for that matter the other two letters, T and G?  Well, referring to Tuesday’s introduction class, these are the 4 base nucleotides that make up the “rungs” in the DNA double helix ladder.

T,A,C,G

T, A, C and G are short for Adenine, Cytosine, Thymine and Guanine.  You can see these nucleotides as they each make up half of the connection between opposite sides of the double helix as it uncoils.  Normally, a T is paired with a C and the A is paired with the G.  However, not always.  When a mutation happens, sometimes the pairing is inverted and a C gets paired with an A or a T gets paired with a G.

When a typical mutation happens, meaning T/C and A/G, it’s called a transition.  When a more unusual mutation happens, meaning C/A, A/C, G/T and T/G, it’s called a transversion.  I think this is what I said the other night, but given how often I use these terms, which is almost never, it would have been easy to get them switched.

I know, by now you’re VERY sorry you asked aren’t you:)

But we’re not quite to the answer yet, so please, bear with me and read on.  Remember, this could qualify you to win the new Genetic Genealogy Trivial Pursuit game whenever that version emerges.  We are almost to the punch line….

In order to make life easier and to eliminate the need for a translation table, the new RSRS refers to mutations a little differently.  You’ve guessed by now, haven’t you.  Yep, you’re right, my mutation shown as C15452a has its own translation table built right in.  The mutation location is 15452.  The normal value, meaning the one Eve had (RSRS), as well as the CRS, was a C.  However, my value is an A, but since it’s a little a, we know that this is a transversion, not a transition.  You can see another transversion at my location 825.

Why is this important in genetic genealogy?  It’s not, really, because it’s already taken care of for you.  If someone else has a value there of C15452T, they simply won’t be shown as a match to me with my value of C15424a.  So you don’t have to figure this out, it’s taken care of for you in the matching routine.  But hey, you wanted to know, and now you do.  Good eye for the catch!

You can read more about the RSRS in the paper by Dr. Behar et al, “A ‘Copernican’ Reassessment of the Human Mitochondrial DNA Tree from its Root” or by visiting the website mtDNA Community launched in conjunction with the paper.  And if you’re really a glutton for punishment, check page 677 in the paper for more about different notations and what they mean for mitochondrial DNA.  There is more than just T, A, C and G for inquiring minds that want to know!

______________________________________________________________

Disclosure

I receive a small contribution when you click on some of the links to vendors in my articles. This does NOT increase the price you pay but helps me to keep the lights on and this informational blog free for everyone. Please click on the links in the articles or to the vendors below if you are purchasing products or DNA testing.

Thank you so much.

DNA Purchases and Free Transfers

Genealogy Services

Genealogy Research

Gene by Gene Announces Landmark DNA DTC Full Genome Sequence

Gene by Gene, the parent company of Family Tree DNA, formally announced it’s direct to consumer (DTC) offering of full sequence human genome testing.

Testing will be performed in their state of the art research center, shown above, in Houston, Texas.  You can read more about Gene by Gene and their 4 divisions, DNA DTC, Family Tree DNA, DNA Traits and DNA Findings at www.genebygene.com.

Family Tree DNA was established 12 years ago to service the Genetic Genealogy market space, which didn’t yet exist at that time.  Family Tree DNA was an innovator in that field, and has brought the same innovative and entrepreneurial spirit to their other companies established since.

This new offering, the first of it’s kind, reaches out to researchers and others in need of “research only” next generation full genomic sequencing.

“Given the explosive demand for accurate, timely, and large-scale next
generation sequencing, we’re pleased to make our Genomics Research Center
available to investigators exploring the cutting edge of research to pioneer and
enhance treatment of disease, enhance quality of life, break new ground in
genealogical inquiry and otherwise advance the science of genomics,” Gene By
Gene President Bennett Greenspan said. “The launch of DNA DTC is the perfect
complement to our other divisions, through which we make genetic testing
advances every day in the fields of ancestry, health and relationship testing.”

Using the Illumina platform, DNA DTC will offer both full genomic sequence and full exome testing, adding these two items to their menu of over 200 types of DNA tests performed.  Gene by Gene’s lab has already processed more than 5 million discrete DNA tests for more than 700,000 individual clients.  Their institutional clients include the National Geographic Society’s Genographic project and other clients such as France’s Institut Pasteur, Israel’s Rabin Medical Center and the University of Utah.

By bringing full genomic sequencing to the public, they have broken the sound barrier in personal genetics, the veritable X-factor.  The full humane genome was first sequenced in 2003 at a cost of about 3 billion dollars.

A full genome sequence still cost about 3 million in 2007, but DNA DTC is offering it today for an amazing $5495.

While consumers will be able to order the full genome (or exome) test, if they want, it comes with no tools, as it is focused at the research community who would be expected to have their own analytical tools.  However, genetic genealogists being who and what they are, I don’t expect the research market will outweigh the consumer market for long, especially when the price threshold reaches about $1000.  For years the “$1000 genome” has been bantered about, and I expect with the next generation of technology, we may see it sooner than later.  The fact that it has dropped from 3 million to $5495 in 5 years is astounding.

Aside from DNA DTC and Family Tree DNA, the other two  Gene by Gene divisions are DNA Traits (www.dnatraits.com)  which provides CLIA Regulated Diagnostic tests for genetic diseases and DNA Findings (www.dnafindings.com)  which provides AABB certified paternity and relationship testing.

Way to go Max and Bennett and everyone at Gene by Gene!  Congratulations!

So, who is going to be the first in the genetic genealogy community to order this test???

______________________________________________________________

Disclosure

I receive a small contribution when you click on some of the links to vendors in my articles. This does NOT increase the price you pay but helps me to keep the lights on and this informational blog free for everyone. Please click on the links in the articles or to the vendors below if you are purchasing products or DNA testing.

Thank you so much.

DNA Purchases and Free Transfers

Genealogy Services

Genealogy Research

Averages, TIP Calculator and One Size Fits All

Averages.  We all know what that means, conceptually.  You add a group of numbers together and divide by the total of the numbers you added together.  For example, 9 number locations that have a value of 10 each totals 90.  If you divide 90 by the number of number locations, 9, you get 10 as the average.  Of course, that’s a very simple example, but the concept applies no matter how many number locations or how big or small the numbers.

Often, we don’t grasp a good working knowledge of how to apply that math concept as it relates to our DNA results.

What I’m referring to here is the TIP calculator provided by Family Tree DNA, but this concept applies equally as well to any TMRCA (Time to Most Recent Common Ancestor) calculation, regardless of who is calculating it.  The underpinnings, are, by necessity, the same.

At Family Tree DNA, the TIP calculator, the little orange button above, is available to you to compare Y-line results to matches and it will give you a rough idea of how long ago you can expect to have a common ancestor.

One of the most common questions I receive reads something like this:

“The TIP calculator says that we should be related at 99% within 12 generations, but my genealogy shows that it should be 8 generations.  What is wrong?”

Or something like this:  “The TIP calculator says we are related, but I have no idea how to interpret any of these numbers.”

The answer is that nothing is wrong and these are ranges of possibilities, based on average mutation rates of individual markers.  Having said that, we know absolutely that mutations are random events.  You can see this demonstrated in the Estes project where Abraham Estes (born 1647) who had 12 sons produced one line who has several people with no mutations as compared to Abraham, and another descendant whose line from another son has 8 mutations in the same  timeframe.  Now it’s obvious that both of these are on the outer bands of the spectrum, and the average is 4, which really is not reflective of either of these lines, but is dead center accurate for two of Abraham’s other sons’ lines.

Recently, I was working with the Nemaha Half-Breed Allottee, a list of names of mixed European/Native American individuals who received individual land allotments in 1860 in Nebraska from the government as a result of an 1830 treaty.  When analyzing the 365 people who had European names, I realized that this is the perfect example of averages and how they do, and don’t, work.  So let’s visit the Nemaha for a minute.

There are 122 different surnames represented, and the average then is that 2.99 people should carry each surname.  365 divided by 122=2.99.  So let’s say 3 people, as it’s very close.

In reality, here’s how the surname distribution breaks down.

Number of People Carrying Surname Number of Surnames
1 54
2 18
3 10
4 12
5 8
6 6
7 4
8 3
9 2
10 0
11 1
12 0
13 0
14 0
15 1
16 0
17 0
18 1

You can see that only 10 surnames actually have 3 people who carry them, for a total of 30 people, or about 12%.  For the remainder, 90 surnames have fewer than 3 people, for a total of 25%, and 63% of the surnames have more than 3 people who carry that surname.

Stated a little differently, this average is accurate for 12% of the people, and inaccurate for 88%. It is close for many.  About 23% fall directly on either side, meaning 2 people or 4 people carry that surname.

So what is the message here?  Averaging tools, TIP included, do the best with what they have, which includes results at both ends of the spectrum.  In this case, it includes the 54 surnames with only one person each, and the 3 surnames who each have over 10 people each, 11, 15 and 18, totaling 44 people.  If these people were trying to make sense of these averages, 3 people per surname, these numbers would be totally irrelevant to them.

So the lesson here is to use these tools as a guideline, and nothing more. You could be in the middle and these tools could apply to your family exactly, or you could be in the family who has 18 people carrying one surname instead of the “average” of 3.

This reminds me very much of the ‘one size fits all” nightshirt that got passed around for some years at home when I was a kid.  “One size fits all” really meant “fits no one” and translated into “no one was happy.”  Of course, if you don’t understand the meaning of “one size fits all” and averages, you might be happy and think you have an answer that you don’t.

______________________________________________________________

Disclosure

I receive a small contribution when you click on some of the links to vendors in my articles. This does NOT increase the price you pay but helps me to keep the lights on and this informational blog free for everyone. Please click on the links in the articles or to the vendors below if you are purchasing products or DNA testing.

Thank you so much.

DNA Purchases and Free Transfers

Genealogy Services

Genealogy Research

Bigfoot is Real???

If a new paper yet to be published and currently undergoing peer review is valid, it appears that Bigfoot, also known as Sasquatch, is indeed, real and a hominid mix, meaning that Sasquatch is a human relative that arose approximately 15,000 years ago as a hybrid cross of modern Homo sapiens with an unknown primate species.

Following five years of research, a team of scientists has sequenced several Sasquatch genomes.  Results show that Bigfoot is a mixture between a human female, about 15,000 years ago, and a male, a previously unknown hominin related to Homo sapiens and other primate species.  Wow.  What a discovery!

This begs several questions.  Is all of the mitochondrial DNA the same, inferring a single maternal ancestor?  They have sequenced 20 different mitochondrial samples.  Given that the mitochondrial DNA is reportedly identical to that of modern humans, we can presume, one would think, that the mitochondrial DNA is Native American, so a member of haplogroup A, B, C, D or X.  Hopefully the forthcoming paper will be more specific.

The scientists fully sequenced three Bigfoot nuclear DNA samples and the results are stunning.  The male is not a contemporary human and they have eliminated both Neanderthal and Denisovian males as possible founders.

Dr. Melba Ketchum, one of the paper’s authors, states that, “The male progenitor that contributed the unknown sequence to this hybrid is unique as its DNA is more distantly removed from humans than other recently discovered hominins like the Denisovan individual. Sasquatch nuclear DNA is incredibly novel and not at all what we had expected. While it has human nuclear DNA within its genome, there are also distinctly non-human, non-archaic hominin, and non-ape sequences. We describe it as a mosaic of human and novel non-human sequence. Further study is needed and is ongoing to better characterize and understand Sasquatch nuclear DNA. Genetically, the Sasquatch are a human hybrid with unambiguously modern human maternal ancestry.”

There are subtle and not so subtle messages buried here as well.  Obviously, for the team to acquire 20 samples to process, there has to be a population of these creatures living in North America.  Of course, everyone has heard of Sasquatch and seen photos and videos, but until this, nothing has been terribly convincing.  There has been no smoking gun.  If this research is valid and passes peer review, it not only confirms that Sasquatch is real, it vindicates many of the people who have had “sightings” over the years.  It becomes the smoking gun.  But as with much science, it raises more  questions than it answers.

For example, are there any non-admixed Sasquatch progenitors left, meaning the males that founded the Sasquatch line with the human female?  How would we tell the difference?  This of course implies that some sort of pre-hominid species existed on this continent before Native Americans arrived from Asia and had existed separate from hominids for a long time.  Is there other evidence of this creature in North America?

Where were these samples collected?  Are the Sasquatch samples studied from across North America or from one region only?  Are all of the Sasquatch related to each other, and how closely?  In other words, were there multiple founder events?  Was the Y-line DNA sequenced and what does it tell us? Were there multiple male founders or did the Sasquatch line arise from a “one time” event?  Do any of the Native tribes in these regions have oral history regarding either Sasquatch or interbreeding with Sasquatch type creatures?

Are there “Sasquatch” in other parts of the world as well?  The Yeti or Abominal Snowman of Nepal seems to be similar, and a scalp purportedly exists from that creature.  If DNA samples outside of North American have been sequenced, are they related to the North American Sasquatch or did they arise separately, assuming they too exist?

And finally, do these creatures have “rights” and are they the same “rights” as humans?  Given that they carry human mitochondrial DNA, and many Native tribes are maternally based, would they be considered “Native American?”  How do we, as humans, deal with this?  Are we learning that humanity is really a continuum?

Indeed, I look forward to seeing this published paper and I hope it is legitimate and not pseudo-science of some sort.  The mere fact that the scientiests have opted for academic publication versus a book or TV documentary certainly alludes to the fact that it is legitimate research.  You can read more about this announcment at these links.  I’ll let you know when the paper becomes available.

http://www.prweb.com/releases/prweb2012/11/prweb10166775.htm

______________________________________________________________

Disclosure

I receive a small contribution when you click on some of the links to vendors in my articles. This does NOT increase the price you pay but helps me to keep the lights on and this informational blog free for everyone. Please click on the links in the articles or to the vendors below if you are purchasing products or DNA testing.

Thank you so much.

DNA Purchases and Free Transfers

Genealogy Services

Genealogy Research

Facebook Link

We’re on Facebook now at www.facebook.com/DNAexplain.

I’m hopeful that reaching out through Facebook will attract some new people to genealogy.

You can also visit the Native Heritage Project Facebook page at www.facebook.com/NativeHeritageProject.

Facebook requires 25 “likes” before they will issue a direct link, so thank to everyone who “liked” these pages.

______________________________________________________________

Disclosure

I receive a small contribution when you click on some of the links to vendors in my articles. This does NOT increase the price you pay but helps me to keep the lights on and this informational blog free for everyone. Please click on the links in the articles or to the vendors below if you are purchasing products or DNA testing.

Thank you so much.

DNA Purchases and Free Transfers

Genealogy Services

Genealogy Research

Thanksgiving, Spilling the Beans and Reaching Out

Everyone in the US and Canada celebrates the holiday of Thanksgiving, although on different dates.  Traditionally, as all children learn in grade school, in the US this holiday celebrates the Pilgrims being helped by the Indians to survive and a feast they jointly held in Plymouth, Massachusetts in 1621.  There is a lot of debate about that event, whether it happened or not, but I think it’s actually irrelevant.  More important is what Thanksgiving has morphed into, what it is today.

It’s a family day, often more so than Christmas, especially in the northern climates.  In my family, and many others, at Thanksgiving you see more extended family than at Christmas, where Christmas is more immediate family.  In the North, travel has become difficult or iffy at best by the end of December, but the end of November generally is still safe.  Now that I’ve said that of course we’ll have a blizzard.

Thanksgiving is the time when my Aunt Verma inadvertently spilled the beans on the “skeleton in the closet” at the dinner table.  You could have heard a pin drop.  Well, before the gasps.

Thanksgiving is the time to ask about those ancestors or family members, even if you think you know the answer.  Because, you may not.  Often, it’s for lack of asking the question or introducing the subject that you don’t learn those stories.

Probably the number one regret of genealogists is that they never reached out when they could.

Today, reaching out isn’t just across the dinner table or while doing dishes, a favorite time to pick the brains of your relatives, it’s about reaching out using new technology.

If you could make contact with someone who has photos of your great-grandmother, wouldn’t you want to do that?  How about someone who has a copy of the family Bible owned by your Revolutionary War ancestor?  Maybe a tin type and journal of your Civil War ancestor.  Who has those today?  Maybe you don’t even know they exist.

If they aren’t in your family, it will take a new form of reaching out to find them.  I’ve celebrated Thanksgiving this week by reaching out to the younger generation.  I don’t mean to stereotype, but let’s face it, you’ll never meet these people on Rootsweb. Where do you find them?  Facebook, that’s where.  Want to find out what pictures their grandma has in the attic?  Well, you have to make contact with them so they will ask their grandma, or tell their grandma to check out your Facebook page.  And yes, more and more, grandma is using Facebook.

Now stop groaning.  I can hear you from here!  I know, I groaned too.  But I did it anyway.  We need to interest young people.  They can DNA test and someday, maybe one  of them will be who you pass the proverbial family torch to.  If you’re like me, it’s not one of your kids, no matter how badly you want it to be. I think I burned them out in courthouses at the copy machine when they were kids.  My bad.

This is not difficult.  If you are not on Facebook, summon up your courage and go to www.facebook.com and sign up.  If you are already on Facebook, skip down 2 or 3 paragraphs to the section on setting up pages and groups.

If you’re really uncertain, you can google about how to get started using Facebook, but it’s actually really easy and intuitive.  You want to be on Facebook because your kids and grandkids are there and you’re going to lose touch with them and how they communicate if you don’t join.  Just do it.

Once you join, just type names into the top bar to look for your friends and family, where it says “search for people, places and things.”  Then send them a friend request.  You’ll see the “Friend” button, just click on it.  This isn’t difficult, you just need to get used to it.  Here are the results when I searched for Jim.

Once you are a friend, you will see what they put on their timeline and their status posts.  These include photos and such.  I see new photos of my grandkids just about every day.  Your news feed aggregates all of the people and projects that you are following.

Of course, you’ll want to post something, eventually, yourself.  The best way to get a conversation started is to ask questions, just like at Thanksgiving.

On Facebook, you do that by typing something in the field that says “What’s on  your mind?”  Facebook is one big informal conversation.

After you get at least a little comfortable with Facebook and your News Feed, you’ll want to set up either a project group or a page.

Here’s what I did.  And by the way, I am not “comfortable” with Facebook but I just did this anyway.  The only way to get comfortable is to work with the software.

I set up two pages and I’m going to set up project groups.  My new pages are ”DNAexplain” and “Native Heritage Project.”  You will have to type those names (minus the quotes) in the search bar at the top of the page at Facebook to find them.  That’s how Facebook works.  Then you click on the image and then click on “like” to connect yourself to them.  So please, do me a favor and “like” both of them.  Facebook requires 25 likes for a new group or page to be recognized as legitimate.

Pages are public.  They are generally for entities, meaning businesses and organizations.  You might want to put a family association there.  ISOGG (International Society of Genetic Genealogists) is there, for example, as is the Lost Colony Research Group.  Everything posted on these pages is available for everyone to see.

Groups can be set up to be entirely public, private or secret, meaning by invitation only.   Facebook has a help page that discusses these differences.  Groups are generally for more personal discussions.  For example, you might choose to form a “by invitation only” intimate family group.  You might choose to set up a Page to advertise your family association and to attract people who are interested in addition to a group for more private discussions.  Remember, the whole point of this exercise it to reach out, so the more public your presence, the better chance you’ll have of attracting interested people.  Be aware however, that these pages are not text searchable and do not have archives like Yahoo Groups or Rootsweb.  But then again, this is for reaching out, not archiving.

To create a page, which is what I recommend for surname projects, scroll all the way down to the bottom of your Facebook page and click where it says, “create a page.”  From there on, Facebook guides you.

To create a group, on the left hand banner, Facebook will show you any groups you are a member of, and at the bottom of the list, it says “create groups.”  Click there and again, Facebook guides you through the rest.

Here is my commitment.  If a Facebook page or group does not exist for each one of my DNA surname or other pet projects, I’ll create one by year end.   Yes, this year, 2012.  There is nothing like the present moment.  I’m reaching out to the next generation.  After all, the old folks are gone now, so I need new information targets:)  Who knows what I’ll find, but if I don’t reach out and try, I’ll find absolutely nothing!  I want more family information to be thankful for by next Thanksgiving!!!  I want to honor those who have gone before by preserving the information about their life.  That is what heritage is.

How about you?  How can you reach out and what do you hope to find?

______________________________________________________________

Disclosure

I receive a small contribution when you click on some of the links to vendors in my articles. This does NOT increase the price you pay but helps me to keep the lights on and this informational blog free for everyone. Please click on the links in the articles or to the vendors below if you are purchasing products or DNA testing.

Thank you so much.

DNA Purchases and Free Transfers

Genealogy Services

Genealogy Research

Otzi Was A Brown Eyed, Left Handed Farmer


Otzi, the mummified man found in 1991 in the Italian alps has provided a huge amount of information to science for one man, especially one who has been dead for more than 5300 years.  Otzi was killed by an arrow to the back, probably bleeding to death, although maybe not right away.  Based on blood analysis, he may have had companions with him who were also injured.

He was an old man at the time, 45.  Most didn’t survive that long.  Surrounding the mummy was his quiver, copper ax, interpreted as a status symbol, knife and other belongings, which were nearly missed when the body was recovered.  He was dressed in hides from multiple species of animals, sported a bear-skin hat and a woven grass cloak.  He had eaten unleavened bread, fruit and deer meat only a couple of hours before his death.  He had also taken herbal medicine suggesting that perhaps his meal didn’t set too well with him.  He had tattoos which may have been related to a healing ritual since they were on or near body parts which showed wear, knees and ankles, which were probably painful to him.  Hair on his clothes tells us he herded cows, sheep and goats.  He was diminutive compared to today’s people at 5’3″ and 110 pounds.

If you think about it, Europe didn’t have a large population then.  Otzi may be an ancestor of many of us. But then again, maybe not, because genetic analysis tells us that he may have suffered from reduced fertility.  But we could easily still be related in some way, as the population was fairly small and the large population of Europe grew from the founders.  Otzi and his family clearly were founders of the European population.

When Otzi was first discovered, the National Geographic Society did a facial reconstruction of Otzi, depicting him as a robust, healthy relatively young-looking man.  More recent cranial imaging capabilities combined with genetic analysis and other fields of research have shown us that indeed, he wasn’t quite so healthy.  Robust Otzi is shown below.  Perhaps this resembled a younger Otzi.

Otzi, at his death, looked like the more recent reconstruction at the top of this blog.

Most recently, last week, at the American Society of Human Genetics meeting, scientists reported that Otzi was a farmer.  While this may not sound remarkable, it is, just the fact that they can determine this, and what his DNA and other similar DNA reveals about migration and settlement patterns.  It turns out that Otzi most closely resembles people from Sardinia, a large island off the west coast of Italy, not the hunter gatherers in the Alps where he was found.

Isotope analysis of his teeth tell us that Otzi did not grow up in the Alps where he died (red balloon), but south about 50 km near the village of Feldthurns (blue balloon).  But he didn’t grow up in Sardinia (yellow balloon), so that connection is further back in time.

In addition, his DNA also resembled the DNA of the farmers of Bulgaria and Sweden, but again, not the hunter-gatherer population.  Not only does this tell us that Otzi was a farmer, but it tells us how and where the farming population settled, and who they were.

http://www.huffingtonpost.com/2012/11/09/otzi-the-icemans-genes-central-europe_n_2099809.html

More interesting info here:

http://www.livescience.com/24666-otzi-iceman-mummy-life-death.html

Otzi, it appears, was left handed, was probably lactose intolerant and had Lyme disease, making him the earliest known case.  He was also more closely related to Neanderthals than Europeans today.  Today’s Europeans uniformly carry roughly between 2% and 4% Neanderthal ancestry.

Otzi’s mitochondrial DNA line may well be extinct.  If not extinct, then no others have yet been discovered.  He is a subgroup of the K1 lineage, named K1o (that is O for Otzi, not a zero.) His Y-line DNA is haplogroup G2a2b.

http://en.wikipedia.org/wiki/%C3%96tzi

National Geographic has funded significant research on Otzi and has provided additional information and reconstruction photos here:

http://news.nationalgeographic.com/news/2011/02/pictures/110225-otzi-iceman-new-face-science-mummy-oetzi/#/iceman-oetzi-otzi-reconstructed-new_32525_600x450.jpg

______________________________________________________________

Disclosure

I receive a small contribution when you click on some of the links to vendors in my articles. This does NOT increase the price you pay but helps me to keep the lights on and this informational blog free for everyone. Please click on the links in the articles or to the vendors below if you are purchasing products or DNA testing.

Thank you so much.

DNA Purchases and Free Transfers

Genealogy Services

Genealogy Research

Smith and Jones

I just love a good mystery – don’t you?  To be good, it has to have some romance of course, a villain, an interesting plot with a twist, a couple red herrings and an unexpected outcome.  Personally, I like happy endings too – I just don’t want them to be too predictable.

Well, welcome to the Smith and Jones mystery.  And no, those names have not been changed to protect anybody.  They are quite real.

When I receive an order for a Personalized DNA Report, I send the client a short questionnaire to complete.  They have the opportunity to tell me why they tested their DNA, their goals, ask any specific questions, and to provide their genealogy so I have something to work with.  In addition, I customize the cover of their report with their family photos if they so desire.

When Mr. Jones returned his questionnaire, in answer to the questions about why he tested, he gave this response:

“My paternal grandfather was the son of an unwed mother.  So my paternal line doesn’t go back very far.  I really hope the DNA can help me find out who my paternal ancestors were.  So far, the indicators are they are Smiths from Bladen County, North Carolina.”

I cringed when I saw this.  Here’s a Jones who thinks he’s a Smith.  How am I ever going to straighten this out with these extremely common surnames?

In the genealogy section, he gave me a little more information.

His paternal grandfather, William Hobson Jones, below, was born in 1902 in Bladenboro, NC to unwed mother Emma Elizabeth Jones.

Those are all the facts I had to work with, other than his DNA results themselves, of course.

To begin, I checked the haplogroup hoping for something exotic that will serve as a differentiator.  R1b1a2-U106 – so no luck there.  However, when I prepared his marker frequency chart, he did have 3 very rare marker values.  Great.  Now we are getting someplace.

I divide marker values into three categories.  Very rare marker values occur in 6% or less of the haplogroup population, rare markers in less than 25%, and the balance are just unremarkable.  It’s the rare and very rare markers that give me something to work with, because they form a very specific genetic family surname “fingerprint.”  In this case, Mr. Jones’ marker 458 carried a value of 15 which occurs in 2% of the haplogroup R1b population, 576 with a value of 16 which occurs 6% of the time and 444 with 14 that occurs only 1% of the time.  These are the litmus paper tests of a real match.  In addition to these very rare marker values, he had 9 additional rare markers that can be used to refine the match criteria.  We’re in good shape for matching.

Mr. Jones had tested at 67 markers, but he had no matches at that level.  However, at 37 markers, he had 3 matches, and they were all to Smith men, none of whom had tested at 67 markers.  Now there’s a good indicator that he was right, that his genetic line is indeed Smith.  His exact match listed his oldest ancestor as being from Germany, but gave no name.  His one mutation match showed his oldest ancestor as Jeremiah Smith born 1795 NC and his 2 mutation match showed no information at all.  None of these matches had uploaded GEDCOM files.  Disappointing. With more information, this would have been much easier, but it wouldn’t be a good mystery without some glitches!

At 25 markers, he only had 7 matches, but at 12 markers, he had a whopping 536.  Obviously his first panel was too vanilla to be very useful, but of course, I did check for additional Smith men.  None to be found.  Just the 3, but those 3 are all very solid.

Sometimes, at this point, projects are a saving grace.  Project administrators are amazing people and put forth a lot of work, sort families, collect genealogies, etc.  The Smith DNA project does not have a public website at Family Tree DNA, but they do have a private site.

http://www.smithsworldwide.org/wwtestcomparisongrp.asp?kitno=’231289

At their site, I found a group of Smiths who match Mr. Jones, descended from one Moses Jones of Bladen County.  Huh?  This stopped me in my tracks for a minute, until I realized that this is my client’s kit number, and the Jones family, meaning Emma’s father’s line, indeed, does go back to a Moses Jones.  This would be irrelevant were it not incorrect, because Moses Jones’ male Y-line does not match the Smiths.  The only Jones line that matches a Smith is the one descended from his daughter Emma who had a child outside of wedlock, apparently by a Smith.

By this time, I was chomping at the bit to work with the genealogy records.  William Hobson Jones was born in 1902, so I was hopeful I could find his mother, Emma Jones, in the 1900 census.  The first rule in begetting is that the begetters must have physical proximity to each other – and the traveling salesman is the exception, not the rule.

Sure enough, in the 1900 census, there was Emma, right with her parents Nathan and Elizabeth Jones.  Emma was much older than I had expected, age 36.  She would have been considered a spinster in that time and place, and was probably considered a burden to her family.  Having a child would not have improved that situation any.

However, we have hit the proverbial jackpot here.  Take a closer look…..at the next door neighbor.

Claudius Smith is the neighbor….but wait….with his wife Glenora Smith.  Ok, let’s see if any of their sons are old enough to be the father of Emma’s child.  Nope, the oldest son is only 13, but Claudius himself is 38, just 2 years older than Emma.  Hmmm…..looks like maybe Claudius is the father, or at least he’s our best candidate right now.  Now Claudius might not be the father, but I’d wager that it is someone in his family, like a brother or uncle perhaps, if it is not him.  This Smith family is the best candidate due to the old begetters proximity rule.

This also might explain why Emma didn’t marry the father.  I wonder if she ever told anyone the identity of the father.  The family today certainly didn’t know.

Simple morbid curiosity got the best of me at this point.  I just had to look in the 1910 census to see if Claudius Smith and the Jones family were still neighbors. Was there a feud?  Did someone move?  Imagine my surprise to see Claudius married to Emma who had borne 4 children by this point.  What happened to Glenora?  And why did my client not tell me about this?  Surely he must have known.  Looking closer, this Emma is all of age 28 and her oldest child is 4….and flipping the census page, Emma Jones, along with her son Willie, age 6, indeed are still living next door, now in her brother’s household.  It seems that perhaps Claudius liked woman named Emma.  Maybe he was a widower when Emma Jones became pregnant.

I wondered if I could connect Claudius Smith with the Jeremiah Smith born in 1795 in NC shown as the oldest ancestor of one of Mr. Jones’ Smith matches.  I checked various sources, and Ancestry had a tree that pushed this particular Smith family back another generation, but not to Jeremiah.  This could probably be done, but not with the time alloted for genealogy in a DNA report.  I needed to look for other tools.  http://trees.ancestry.com/owt/person.aspx?pid=19139247

Chess Smith is shown as Claudius’s father and Elizabeth Ann Blackburn as his mother.  And yes, I’m fully aware that online trees should not be taken at face value, but they are good starting points and cannot be presumed to be incorrect either, especially if they confirm a suspected fact.  In this case, that didn’t happen – no Jeremiah.

Fortunately, Mr. Jones had also taken a Family Finder test.  He of course had Smith matches.  Who doesn’t?  But he also had three Blackburn matches.  The addition of this single female line surname gave me something concrete to look for.  I suggested that Mr. Jones contact his Blackburn autosomal matches to see if they can connect to the Chess Smith line.

So, at the end of the day that began with some level of apprehension that I might not be able to help Mr. Jones identify his genetic paternal line, we had a great research plan in hand.

We had discovered that the neighbor’s name was Smith, and he was married with 11 children in 1900, which might just explain why Emma never married the father of her child.  Of course, there might be other reasons too, like the father wasn’t Claudius, but another Smith relative.  It looks very promising, using autosomal tools to find Chess Smith’s wife’s surname, Blackburn, that this is indeed the correct Smith family.

Mr. Jones has some genealogy homework to do on the Chess Smith line, and some contact homework to do with his Blackburn matches, but now he does indeed have the information along with the tools he needs to solve the Jones-Smith mystery and break down that brick wall!

And thank you, Mr. Jones for permission to share your exciting family story!

______________________________________________________________

Disclosure

I receive a small contribution when you click on some of the links to vendors in my articles. This does NOT increase the price you pay but helps me to keep the lights on and this informational blog free for everyone. Please click on the links in the articles or to the vendors below if you are purchasing products or DNA testing.

Thank you so much.

DNA Purchases and Free Transfers

Genealogy Services

Genealogy Research