Mitotree is born and I can hardly contain my excitement.
The Million Mito R&D team members, along with many others at FamilyTreeDNA, are proud to introduce the new Mitotree and mtDNA Discover, which were brought to life thanks to one pivotal entrepreneurial figure, Bennett Greenspan, whose support and vision set the ball in motion and made Mitotree possible.
Left to right, the Million Mito science team is:
- Goran Runfeldt, Head of R&D at FamilyTreeDNA
- Dr. Paul Maier, Senior Population Geneticist at FamilyTreeDNA
- Roberta Estes, DNAexplain, scientist, blogger, author, genetic genealogist, and Genographic Affiliate Researcher
- Dr. Miguel Vilar, Genetic Anthropologist, Lead Scientist with the Genographic Project, and Professor at the University of Maryland
- Bennett Greenspan, President Emeritus of FamilyTreeDNA, and avid genealogist
- John Detsikas, Front End Developer who is responsible for the user interface for both Y-DNA Discover and now mtDNA Discover
The Million Mito Project Inception
The Million Mito Project was launched at RootsTech 2020 and encouraged people to test their mitochondrial DNA, both for their genealogy and to help build the database. More than a million samples were candidates, but only high-quality, full sequence results were used. In the process of building the tree, additional samples were incorporated from other public sources for tree construction.
Drum Roll – The Mitotree
A beta version of the Mitotree is being released today, and boy, is this a big deal.
Before we discuss the rest of what’s coming, I need to mention that the Mitotree is now evergreen, meaning that the tree will be updated periodically, as will mtDNA Discover. This lifetime value is included with the cost of your test, so there’s nothing more to purchase.
Haplogroups will change from time to time, as the tree does, so don’t fall in love with yours, and definitely, no tattoos😊
I’m going to be speaking in terms of “we,” meaning the Million Mito team who built the Mitotree and mtDNA Discover, plus an amazing team of FamilyTreeDNA folks who were absolutely essential in getting this out the door and to you.
The Mitotree is new from the ground up, and yes, haplogroup naming consistency with PhyloTree has been maintained where possible.
One of the unanticipated challenges we encountered was that the 2016 PhyloTree had to be recreated, essentially reverse engineered, to determine the rules they used regarding mutations for haplogroup creation. In other words, which mutations were valid and reliable, which weren’t, determining their relative importance, and so forth.
After the existing 2016 tree was recreated, the next hurdle to overcome was that none of the existing phylogenetic software used in academia would scale from 24,000 samples and 5500 subclades to more than a quarter million samples and 40,000 haplogroups, so that software had to be designed and written by R&D team members.
More information about this process will be forthcoming shortly, and a paper will be published with our methodology, but for right now, let’s look at the user experience and what’s being released now.
Here’s what’s coming today and over the next few days.
The beta Mitotree includes:
- Over 40,000 branches
- Over 250,000 mtFull Sequences from FTDNA
- Over 10,000 third-party full sequences from GenBank, 1000 Genomes, etc.
- Over 1000 Ancient Connections
- Over 100 Notable Connections
More is on the way.
The new Mitotree is the tree provided in several formats within mtDNA Discover. You can view the public version of the tree, here, or sign on to your FamilyTreeDNA account and click through from your dashboard to see more.
Today’s Releases
The Mitotree doesn’t exist in a vacuum, so several updates and new features will be rolling out today.
- mtDNA Discover, which includes the new Mitotree
- New customer haplogroups for those who have taken mtFull sequence tests
- New mtDNA matches page
New Haplogroups
New haplogroups have been calculated for FamilyTreeDNA customers who have taken the full sequence test. Those who have taken only the HVR1 or HVR1/HVR2 tests are encouraged to upgrade to the full sequence test.
Not everyone will receive a new Mitotree haplogroup that is different from their classic haplogroup, but most people will. Your original haplogroup is displayed with the classic tag, and the new Mitotree haplogroup with the beta tag.
If your classic and Mitotree haplogroups are the same, it means that either you have no more private variants (mutations) available to form a new haplogroup, or no one else from your lineage has tested yet.
New mtDNA Matches Page
If you click on your mtDNA matches, you’ll notice that the page has been redesigned to look and function like the other FamilyTreeDNA match pages.
If you click to view your matches, you’ll be able to view both the “old” classic haplogroup, and your matches’ new Mitotree haplogroup, plus a new haplotype if they have one. We will talk about haplotypes in a minute.
The people you match are the same as before, but matches may be recalculated in the future.
If you click through to the new mtDNA Discover from your dashboard, you’ll be able to view the public portion of mtDNA Discover, plus the additional customized information provided to FamilyTreeDNA mtFull sequence customers.
mtDNA Discover
If you have taken a full sequence test, sign on to your account to view your new haplogroup, then click on the new mtDNA Discover icon on your dashboard.
If you haven’t taken the mtFull sequence test, but the partial HVR1 or HVR2 versions, you can still view mtDNA Discover on your dashboard, but without the mtFull customization.
Customization that occurs exclusively for FamilyTreeDNA mtFull sequence customers includes:
- Most detailed placement of your branch on Mitotree
- Haplotype clusters
- Additional Ancient Connections
- Additional Notable Connections
- The Match Time Tree
- Globetrekker (coming soon)
- The Group Time Tree (coming soon)
mtDNA Discover is similar to Y-DNA Discover.
You’ll be able to view a dozen new reports about your haplogroup in addition to the tools provided on your dashboard.
The new Mitotree can be viewed in several formats, each with its unique benefit.
- Time Tree – a genetic tree that shows when each haplogroup was formed, plus a country flag for where present-day testers report as the location of their earliest known ancestor (EKA)
- Classic Tree – a more traditional view of a phylogenetic tree, including the number of testers on each branch, the variants, or mutations that define the haplogroup, the era and approximate date of formation, and other details about the tree topology
- Scientific Details Variants Tab – shows the variants that differ in each haplogroup as you reach back in time
- Ancestral Path for the selected haplogroup – outlines your path back to early humans, including Denisovans.
- Match Time Tree for you and your matches (must be signed in to your account and click on mtDNA Discover icon)
- Group Time Tree (coming soon) for those who have joined projects
Match Time Tree
The Match Time Tree is extremely useful because it overlays your matches, plus their earliest known ancestors (EKA), on a genetic Time Tree, by haplogroup and haplotype, so you can see how you may be related, and when.
You can also see your matches that have now fallen into neighboring haplogroups, which suggests that they probably aren’t as genealogically close as people in your haplogroup. However, that’s not always the case, because mutations can occur at any time.
Haplotype Clusters
A haplotype cluster is a new concept introduced specifically for genealogists with the new Mitotree. Haplotypes are identified by numbered “F” groups. Three are shown, below.
There may be groups of people within a haplogroup that have exactly the same mutations, or genetic signature, and no additional mutations. Still, they may not form a new haplogroup. There could be several reasons for not forming a new haplogroup, including known SNP locations where mutations occur that are known to be unstable, such as location 315, which tends to accumulate random insertions and is ignored because of its known instability.
When multiple people share an exactly identical signature, meaning all of the same mutations, they are shown within a haplotype “F” cluster to provide additional specificity to the tree.
The haplotype has been designed to provide additional granularity to the tree and genealogically relevant information. The haplotype “Fxxxxxx” numbers are randomly generated and have no special meaning.
A word of caution here. While the haplotype sequences are identical, it is still possible that another tester from outside the cluster could be a closer relative. For example, they could have accumulated a fast mutating SNP in the last few generations, which would give them a different signature.
Someone who is actually genealogically close to you may be in a different haplotype, or no haplotype at all because no one matches them exactly. For example, if your aunt or sister has a heteroplasmy, they are a close relative and will be in your haplogroup, but won’t be in your haplotype cluster because of the heteroplasmy. So don’t ignore matches who aren’t in your haplotype.
In the above example, under haplogroup V71b, there is one group of three people of unknown origin, meaning they didn’t enter any location for their earliest known ancestor, plus haplotype F9712482 – all of whom are identical matches to each other, but don’t form a new haplogroup.
Beneath V71b is haplogroup V71b1 with nine people, plus two haplotype clusters. F1965416 consists of two people, and F8189900 consists of 16 people.
You can also see haplotype clusters bracketed on any of the Time Trees in mtDNA Discover as well.
More to Come
There’s more information to come in the next few days and weeks, and at RootsTech. I’ll be writing articles when I get back.
For now, take a look to see if you have a new haplogroup. The new haplogroup rollout is being staggered, and you should receive an email when yours has been posted. But there’s no need to wait. Go ahead, sign in and check now, check out mtDNA Discover, and have fun.
Guaranteed, you’ll learn something new, and you may discover the key to a new ancestor!
Resources
Here are additional resources about the new Mitotree, mtDNA Discover, and the associated updates:
- Updated mtDNA Haplotree: 35,000 New Branches for Genealogy Research – FamilyTreeDNA’s announcement article
- Accessing mtDNA Discover™
- Using the mtDNA Discover™ Haplogroup Story Report
- Using the mtDNA Discover™ Classic Tree
- Understanding the mtDNA Haplotree
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